TCL1A

T-cell leukemia/lymphoma protein 1A is a protein that in humans is encoded by the TCL1A gene.^[5][6][7]

TCL1A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JSG
Identifiers
Aliases	TCL1A, TCL1, T-cell leukemia/lymphoma 1A, T cell leukemia/lymphoma 1A, TCL1 family AKT coactivator A
External IDs	OMIM: 186960; MGI: 1097166; HomoloGene: 7565; GeneCards: TCL1A; OMA:TCL1A - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.13 Start 95,709,947 bp[1] End 95,714,196 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 E|12 55.28 cM Start 105,183,009 bp[2] End 105,189,052 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte gonad granulocyte lymph node appendix spleen blood testicle bone marrow Top expressed in zygote secondary oocyte primary oocyte blastocyst morula embryo ovary CA3 field gastrula Gonadal ridge More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein kinase binding identical protein binding protein serine/threonine kinase activator activity Cellular component cytoplasm endoplasmic reticulum intracellular membrane-bounded organelle nucleus protein-containing complex Biological process multicellular organism development positive regulation of cell population proliferation positive regulation of mitochondrial membrane potential positive regulation of protein oligomerization positive regulation of peptidyl-serine phosphorylation negative regulation of apoptotic process protein homotrimerization cellular response to tumor necrosis factor positive regulation of protein serine/threonine kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8115 21432 Ensembl ENSG00000100721 ENSMUSG00000041359 UniProt P56279 P56280 RefSeq (mRNA) NM_001098725 NM_021966 NM_001289468 NM_009337 NM_001309484 NM_001309485 RefSeq (protein) NP_001092195 NP_068801 NP_001092195.1 NP_068801.1 NP_001276397 NP_001296413 NP_001296414 NP_033363 Location (UCSC) Chr 14: 95.71 – 95.71 Mb Chr 12: 105.18 – 105.19 Mb PubMed search [3] [4]
Wikidata
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Interactions

TCL1A has been shown to interact with AKT1^[8][9][10] and AKT2.^[8][9]