Capecitabine
Chemical compound / From Wikipedia, the free encyclopedia
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Capecitabine, sold under the brand name Xeloda among others, is a anticancer medication used to treat breast cancer, gastric cancer and colorectal cancer.[2] For breast cancer it is often used together with docetaxel.[3] It is taken by mouth.[3]
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Pronunciation | /kæpɪˈsaɪtəbiːn/ |
Trade names | Xeloda, Xitabin, Kapetral, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a699003 |
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Routes of administration | By mouth |
Drug class | chemotherapy agent |
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Bioavailability | Extensive |
Protein binding | < 60% |
Metabolism | liver, to 5'-DFCR, 5'-DFUR (inactive); neoplastic tissue, 5'-DFUR to active fluorouracil |
Elimination half-life | 38–45 minutes |
Excretion | kidney (95.5%), faecal (2.6%) |
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ECHA InfoCard | 100.112.980 |
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Formula | C15H22FN3O6 |
Molar mass | 359.354 g·mol−1 |
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Common side effects include abdominal pain, vomiting, diarrhea, weakness, and rashes.[3] Other severe side effects include blood clotting problems, allergic reactions, heart problems such as cardiomyopathy, and low blood cell counts.[3] Use during pregnancy may result in harm to the fetus.[3] Capecitabine, inside the body, is converted to 5-fluorouracil (5-FU) through which it acts.[3] It belongs to the class of medications known as fluoropyrimidines, which also includes 5-FU and tegafur.[4]
Capecitabine was patented in 1992 and approved for medical use in 1998.[5] It is on the World Health Organization's List of Essential Medicines.[6]