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Telomere

Region of repetitive nucleotide sequences on chromosomes

A telomere is a region of repetitive nucleotide sequences associated with specialized proteins at the ends of linear chromosomes. Telomeres are a widespread genetic feature most commonly found in eukaryotes. In most, if not all species possessing them, they protect the terminal regions of chromosomal DNA from progressive degradation and ensure the integrity of linear chromosomes by preventing DNA repair systems from mistaking the very ends of the DNA strand for a double-strand break.

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File:Telomere_caps.gifFile:Dnareplication.svgFile:Telosome.pngFile:Synthesis_of_chromosome_ends_by_telomerase.svgFile:Hayflick_Limit_(1).svg
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  • 1938The existence of a special structure at the ends of chromosomes was proposed by Hermann Joseph Muller.
  • 1939The existence of a special structure at the ends of chromosomes was proposed by Barbara McClintock.
  • Early 1970sAlexey Olovnikov recognized the "end replication problem" of chromosomes.
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