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Ciwon Daji Epigenetics
From Wikipedia, the free encyclopedia
Ciwon daji epigenetics shine nazarin gyare-gyaren epigenetic zuwa DNA na kwayoyin cutar kansa wanda ba ya haɗa da canji a cikin jerin nucleotide, amma a maimakon haka ya haɗa da canji a yadda aka bayyana lambar kwayoyin halitta. Hanyoyin Epigenetic suna da mahimmanci don kula da jerin al'ada na takamaiman maganganun kwayoyin halitta na nama kuma suna da mahimmanci don ci gaba na al'ada. [1] Wataƙila suna da mahimmanci, ko ma mafi mahimmanci, fiye da maye gurbin kwayoyin halitta a cikin canjin tantanin halitta zuwa kansa. Rikicin hanyoyin epigenetic a cikin cututtukan daji, na iya haifar da asarar bayyanar kwayoyin halittar da ke faruwa kusan sau 10 akai-akai ta hanyar yin shiru na rubutu (wanda ya haifar da haɓakar epigenetic hypermethylation na tsibiran CpG ) fiye da maye gurbi. Kamar yadda Vogelstein et al. nuna, a cikin ciwon daji na launin fata yawanci ana samun kusan maye gurbin direba 3 zuwa 6 da 33 zuwa 66 hitchhiker ko maye gurbin fasinja.[2] Duk da haka, a cikin ciwace-ciwacen hanji idan aka kwatanta da kusa da mucosa na al'ada na al'ada, akwai kimanin 600 zuwa 800 tsibiran methylated CpG a cikin masu inganta kwayoyin halitta a cikin ciwace-ciwacen ƙwayoyi yayin da waɗannan tsibiran CpG ba su da methylated a cikin mucosa kusa.[3][4][5] Yin amfani da sauye-sauye na epigenetic yana kuma riƙe da babban alƙawari don rigakafin ciwon daji, ganowa, da jiyya.[6][7] A cikin nau'ikan ciwon daji daban-daban, nau'ikan nau'ikan nau'ikan epigenetic na iya rikicewa, kamar yin shiru na ƙwayoyin cuta masu hana ƙari da kunna oncogenes ta hanyar canza tsarin methylation na tsibirin CpG, gyare-gyaren histone, da dysregulation na sunadaran ɗaurin DNA. Ana amfani da magunguna da yawa waɗanda ke da tasirin epigenetic yanzu a yawancin waɗannan cututtuka.
![Thumb image](http://upload.wikimedia.org/wikipedia/commons/thumb/2/22/Normal-cancer-epigenome.png/640px-Normal-cancer-epigenome.png)
![Thumb image](http://upload.wikimedia.org/wikipedia/commons/thumb/2/28/Epigenetic_alterations_in_tumour_progression.svg/320px-Epigenetic_alterations_in_tumour_progression.svg.png)
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specialty (en) ![]() | |
Bayanai | |
Ƙaramin ɓangare na |
academic discipline (en) ![]() |
Bangare na |
epigenetics (en) ![]() |
Is the study of (en) ![]() |
gene expression (en) ![]() |