인터루킨 6

인터루킨 6(IL6,IL-6,Interleukin 6)은 전 염증성 사이토카인(cytokine) 및 항 염증성 미오킨(myokine) 둘 다로서 작용하는 인터루킨이다. 인간에서는 IL6 유전자에 의해 암호화된다.^[5]

IL6
사용 가능한 구조 PDB 동원체 검색: PDBe RCSB PDB ID 코드 목록 4O9H, 1ALU, 1IL6, 1P9M, 2IL6, 4CNI, 4J4L, 4NI7, 4NI9, 4ZS7
식별자
다른 이름	IL6, BSF2, HGF, HSF, IFNB2, IL-6, BSF-2, CDF, IFN-beta-2, interleukin 6
외부 ID	OMIM: 147620 MGI: 96559 HomoloGene: 502 GeneCards: IL6
유전자 위치 (인간) 염색체 7번 염색체[1] 자리 7p15.3 시작 22,725,884 bp[1] 끝 22,732,002 bp[1]
유전자 위치 (쥐) 염색체 5번 염색체 (쥐)[2] 자리 5 B1|5 15.7 cM 시작 30,218,112 bp[2] 끝 30,224,979 bp[2]
RNA 발현 패턴 Bgee 인간 쥐(동원체) 최상위 발현 cartilage tissue 대정맥 쓸개 왼자궁관 생식샘 민무늬근 mucosa of urinary bladder upper lobe of left lung 랑게르한스섬 고환 최상위 발현 배 stroma of bone marrow 주머니배 endothelial cell of lymphatic vessel spermatocyte spermatid 과립구 lumbar spinal ganglion 랑게르한스섬 atrioventricular valve 추가 참조 발현 데이터 BioGPS 추가 참조 발현 데이터
유전자 온톨로지 분자 함수 사이토카인 활성 growth factor activity interleukin-6 receptor binding 단백질 결합 세포 성분 세포밖공간 interleukin-6 receptor complex 세포 바깥쪽 endoplasmic reticulum lumen 생물학적 과정 regulation of angiogenesis positive regulation of translation platelet activation 체액성 면역 반응 defense response to virus response to peptidoglycan neuron projection development defense response to Gram-positive bacterium negative regulation of fat cell differentiation positive regulation of peptidyl-serine phosphorylation positive regulation of leukocyte chemotaxis positive regulation of T cell proliferation positive regulation of interleukin-6 production positive regulation of peptidyl-tyrosine phosphorylation positive regulation of acute inflammatory response inflammatory response negative regulation of collagen biosynthetic process positive regulation of MAPK cascade hepatic immune response monocyte chemotaxis positive regulation of DNA-binding transcription factor activity 세포자멸사 과정의 하향조절 조골세포 분화의 상향조절 전사인자 NF-kB 활성의 상향조절 acute-phase response 면역반응 regulation of vascular endothelial growth factor production positive regulation of chemokine production negative regulation of lipid storage neutrophil mediated immunity positive regulation of smooth muscle cell proliferation positive regulation of type B pancreatic cell apoptotic process response to glucocorticoid defense response to Gram-negative bacterium positive regulation of cell population proliferation positive regulation of apoptotic process positive regulation of B cell activation 번역 후 변형 신호전달 수용체 활성의 조절 positive regulation of tyrosine phosphorylation of STAT protein neutrophil apoptotic process negative regulation of cell population proliferation positive regulation of gene expression endocrine pancreas development negative regulation of bone resorption positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II glucagon secretion cellular response to hydrogen peroxide cellular response to lipopolysaccharide T-helper 17 cell lineage commitment positive regulation of T-helper 2 cell cytokine production negative regulation of interleukin-1-mediated signaling pathway cytokine-mediated signaling pathway interleukin-6-mediated signaling pathway positive regulation of receptor signaling pathway via JAK-STAT 신호전달 출처: Amigo / QuickGO
동원체 종 인간 쥐 앙트레 3569 16193 앙상블 ENSG00000136244 ENSMUSG00000025746 유니프롯 P05231 P08505 RefSeq (mRNA) NM_000600 NM_001318095 NM_001371096 NM_031168 NM_001314054 RefSeq(단백질) NP_000591 NP_001305024 NP_001358025 NP_001300983 NP_112445 위치(UCSC) Chr 7: 22.73 – 22.73 Mb Chr 5: 30.22 – 30.22 Mb PubMed 검색 [3] [4]
위키데이터
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• 인터루킨 4