TLR4(또는 톨유사수용체4, Toll-like receptor 4, CD284)는 TLR4 유전자에 의해 발현되는 단백질로, 유형인식수용체의 일종이다. LPS를 인식하여 활성화된다.^[5]

간략 정보 사용 가능한 구조, PDB ...

TLR4
사용 가능한 구조 PDB 동원체 검색: PDBe RCSB PDB ID 코드 목록 4G8A, 2Z62, 2Z63, 2Z65, 2Z66, 3FXI, 3UL7, 3UL8, 3UL9, 3ULA
식별자
다른 이름	TLR4, ARMD10, CD284, TLR-4, TOLL, toll like receptor 4
외부 ID	OMIM: 603030 MGI: 96824 HomoloGene: 41317 GeneCards: TLR4
유전자 위치 (인간) 염색체 9번 염색체[1] 자리 9q33.1 시작 117,704,175 bp[1] 끝 117,724,735 bp[1]
유전자 위치 (쥐) 염색체 4번 염색체 (쥐)[2] 자리 4 C1|4 34.66 cM 시작 66,745,821 bp[2] 끝 66,848,521 bp[2]
RNA 발현 패턴 Bgee 인간 쥐(동원체) 최상위 발현 단핵구 아킬레스건 혈액 골수 해면뼈 비장 과립구 오른허파 쓸개 골수세포 최상위 발현 lumbar spinal ganglion 대동맥 판막 상행대동맥 과립구 decidua epithelium of stomach stroma of bone marrow endothelial cell of lymphatic vessel 자궁경부 mucous cell of stomach 추가 참조 발현 데이터 BioGPS 추가 참조 발현 데이터
유전자 온톨로지 분자 함수 lipopolysaccharide immune receptor activity 지질다당류 결합 단백질 결합 transmembrane signaling receptor activity 세포 성분 세포질 세포막 perinuclear region of cytoplasm 세포 표면 integral component of membrane 세포막 endosome membrane intrinsic component of plasma membrane integral component of plasma membrane lipopolysaccharide receptor complex external side of plasma membrane 생물학적 과정 positive regulation of MHC class II biosynthetic process positive regulation of JNK cascade TRIF-dependent toll-like receptor signaling pathway cellular response to mechanical stimulus positive regulation of interleukin-8 production positive regulation of ERK1 and ERK2 cascade T-helper 1 type immune response positive regulation of platelet activation positive regulation of interleukin-1 production positive regulation of stress-activated MAPK cascade positive regulation of NLRP3 inflammasome complex assembly positive regulation of interleukin-12 production positive regulation of interferon-alpha production I-kappaB phosphorylation positive regulation of nitric-oxide synthase biosynthetic process positive regulation of B cell proliferation 세균에 대한 방어 반응 positive regulation of interleukin-6 production activation of innate immune response positive regulation of tumor necrosis factor production negative regulation of tumor necrosis factor production 선천면역 negative regulation of interleukin-17 production I-kappaB kinase/NF-kappaB signaling positive regulation of interferon-beta production positive regulation of inflammatory response toll-like receptor 4 signaling pathway positive regulation of macrophage cytokine production positive regulation of interleukin-10 production 면역 과정 astrocyte development intestinal epithelial structure maintenance positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway response to lipopolysaccharide cellular response to lipoteichoic acid 전사인자 NF-kB 활성의 상향조절 면역반응 negative regulation of interleukin-23 production regulation of inflammatory response positive regulation of chemokine production lipopolysaccharide-mediated signaling pathway detection of fungus positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway negative regulation of interferon-gamma production response to bacterium negative regulation of osteoclast differentiation B cell proliferation involved in immune response positive regulation of nitric oxide biosynthetic process negative regulation of interleukin-6 production positive regulation of interferon-gamma production nitric oxide production involved in inflammatory response MyD88-dependent toll-like receptor signaling pathway regulation of dendritic cell cytokine production positive regulation of gene expression negative regulation of ERK1 and ERK2 cascade I-kB/NF-kB 신호전달의 상향조절 macrophage activation detection of lipopolysaccharide cellular response to lipopolysaccharide positive regulation of lymphocyte proliferation positive regulation of transcription by RNA polymerase II MyD88-independent toll-like receptor signaling pathway 신호전달 inflammatory response defense response to Gram-negative bacterium toll-like receptor signaling pathway necroptosis apoptotic signaling pathway negative regulation of MyD88-independent toll-like receptor signaling pathway 출처: Amigo / QuickGO
동원체 종 인간 쥐 앙트레 7099 21898 앙상블 ENSG00000136869 ENSMUSG00000039005 유니프롯 O00206 Q9QUK6 RefSeq (mRNA) NM_138557 NM_003266 NM_138554 NM_138556 NM_021297 RefSeq(단백질) NP_003257 NP_612564 NP_612567 NP_067272 위치(UCSC) Chr 9: 117.7 – 117.72 Mb Chr 4: 66.75 – 66.85 Mb PubMed 검색 [3] [4]
위키데이터
인간 보기/편집 쥐 보기/편집

닫기