트롬빈

트롬빈(영어: Thrombin)은 혈액 응고에 관련되는 단백질 분해효소로, 혈장 속에서는 전구체인 프로트롬빈(prothrombin)으로 존재한다. ^[5]

F2
사용 가능한 구조 PDB 동원체 검색: PDBe RCSB PDB ID 코드 목록 1A2C, 1A3B, 1A3E, 1ABI, 1ABJ, 1AD8, 1AE8, 1AI8, 1AIX, 1AWF, 1AWH, 1AY6, 1B5G, 1B7X, 1BA8, 1BB0, 1BCU, 1BHX, 1BMM, 1BMN, 1BTH, 1C1U, 1C1V, 1C1W, 1C4U, 1C4V, 1C4Y, 1C5L, 1C5N, 1C5O, 1CA8, 1D3D, 1D3P, 1D3Q, 1D3T, 1D4P, 1D6W, 1D9I, 1DE7, 1DIT, 1DM4, 1DOJ, 1DWB, 1DWC, 1DWD, 1DX5, 1E0F, 1EB1, 1EOJ, 1EOL, 1FPC, 1G30, 1G32, 1G37, 1GHV, 1GHW, 1GHX, 1GHY, 1GJ4, 1GJ5, 1H8D, 1H8I, 1HAI, 1HAO, 1HAP, 1HBT, 1HLT, 1HUT, 1HXE, 1HXF, 1IHS, 1JMO, 1JOU, 1JWT, 1K21, 1K22, 1KTS, 1KTT, 1LHC, 1LHD, 1LHE, 1LHF, 1LHG, 1MH0, 1MU6, 1MU8, 1MUE, 1NM6, 1NRN, 1NRO, 1NRP, 1NRQ, 1NRR, 1NRS, 1NT1, 1NU7, 1NU9, 1NY2, 1NZQ, 1O0D, 1O2G, 1O5G, 1OOK, 1OYT, 1P8V, 1PPB, 1QBV, 1QHR, 1QJ1, 1QJ6, 1QJ7, 1QUR, 1RD3, 1RIW, 1SB1, 1SFQ, 1SG8, 1SGI, 1SHH, 1SL3, 1SR5, 1T4U, 1T4V, 1TA2, 1TA6, 1TB6, 1THP, 1THR, 1THS, 1TMB, 1TMU, 1TOM, 1TQ0, 1TQ7, 1TWX, 1UVS, 1VR1, 1VZQ, 1W7G, 1WAY, 1WBG, 1XM1, 1XMN, 1YPE, 1YPG, 1YPJ, 1YPK, 1YPL, 1YPM, 1Z71, 1Z8I, 1Z8J, 1ZGI, 1ZGV, 1ZRB, 2A0Q, 2A2X, 2A45, 2AFQ, 2ANK, 2ANM, 2B5T, 2BDY, 2BVR, 2BVS, 2BVX, 2BXT, 2BXU, 2C8Y, 2FEQ, 2FES, 2GDE, 2GP9, 2H9T, 2HGT, 2HNT, 2HPP, 2HPQ, 2HWL, 2JH0, 2JH6, 2OD3, 2PGB, 2PGQ, 2PW8, 2R2M, 2THF, 2ZFQ, 2ZFR, 2ZG0, 2ZHE, 2ZHF, 2ZHW, 2ZI2, 2ZIQ, 2ZNK, 2ZO3, 3B23, 3B9F, 3BEF, 3BEI, 3BF6, 3BIU, 3BIV, 3BV9, 3C1K, 3C27, 3D49, 3DA9, 3DD2, 3DT0, 3DUX, 3E6P, 3EE0, 3EQ0, 3F68, 3GIC, 3GIS, 3HAT, 3HKJ, 3HTC, 3JZ2, 3LDX, 3LU9, 3NXP, 3P17, 3P6Z, 3P70, 3PO1, 3QGN, 3QLP, 3QTO, 3QTV, 3QWC, 3QX5, 3R3G, 3RLW, 3RLY, 3RM0, 3RM2, 3RML, 3RMM, 3RMN, 3RMO, 3S7H, 3S7K, 3SHA, 3SHC, 3SI3, 3SI4, 3SQE, 3SQH, 3SV2, 3T5F, 3TU7, 3U69, 3U8O, 3U8R, 3U8T, 3U98, 3U9A, 3UTU, 3UWJ, 3VXE, 3VXF, 4BAH, 4BAK, 4BAM, 4BAN, 4BAO, 4BAQ, 4BOH, 4DIH, 4DII, 4DT7, 4DY7, 4E05, 4E06, 4E7R, 4H6S, 4H6T, 4HFP, 4HTC, 4THN, 5GDS, 7KME, 8KME, 1A46, 1A4W, 1A5G, 1A61, 1AFE, 1AHT, 1DWE, 1FPH, 1HAG, 1HAH, 1HDT, 1HGT, 1IHT, 1NO9, 1TBZ, 1TMT, 1UMA, 2C8W, 2C8X, 2C8Z, 2C90, 2C93, 2CF8, 2CF9, 2CN0, 2JH5, 2PKS, 2UUF, 2UUJ, 2UUK, 2V3H, 2V3O, 2ZC9, 2ZDA, 2ZDV, 2ZF0, 2ZFF, 2ZFP, 2ZGB, 2ZGX, 2ZHQ, 3DHK, 3EGK, 3JZ1, 3K65, 3PMH, 3QDZ, 4AX9, 4AYV, 4AYY, 4AZ2, 4CH2, 4CH8, 4HZH, 4I7Y, 4LOY, 4LXB, 4LZ1, 4LZ4, 4MLF, 4N3L, 4NZE, 4NZQ, 4O03, 4RKJ, 4RKO, 4RN6, 4YES, 4UD9, 4UDW, 4UE7, 4UEH, 5AF9, 5AFY, 5AFZ, 5AHG, 5CMX, 4UFD, 5EDM, 5E8E, 5EDK, 4UFE, 4UFG, 4UFF, 5A2M, 5JDU
식별자
다른 이름	F2, PT, RPRGL2, THPH1, coagulation factor II, thrombin
외부 ID	OMIM: 176930 MGI: 88380 HomoloGene: 426 GeneCards: F2
유전자 위치 (인간) 염색체 11번 염색체[1] 자리 11p11.2 시작 46,719,196 bp[1] 끝 46,739,506 bp[1]
유전자 위치 (쥐) 염색체 2번 염색체 (쥐)[2] 자리 2 E1|2 50.63 cM 시작 91,455,665 bp[2] 끝 91,466,759 bp[2]
RNA 발현 패턴 Bgee 인간 쥐(동원체) 최상위 발현 간오른엽 고환 oocyte secondary oocyte cerebellar hemisphere right hemisphere of cerebellum 오금동맥 tibial arteries fundus 배 최상위 발현 left lobe of liver fetal liver hematopoietic progenitor cell 쓸개 난황낭 태아 sexually immature organism 상실배 primary oocyte secondary oocyte 수정란 추가 참조 발현 데이터 BioGPS 추가 참조 발현 데이터
유전자 온톨로지 분자 함수 calcium ion binding signaling receptor binding 펩티데이스 활성 가수분해효소 활성 growth factor activity 세린 펩티데이스 활성 thrombospondin receptor activity 단백질 결합 세린 엔도펩티데이스 활성 지질다당류 결합 헤파린 결합 enzyme activator activity 세포 성분 엑소좀 blood microparticle endoplasmic reticulum lumen Golgi lumen 세포막 세포밖공간 세포 바깥쪽 external side of plasma membrane collagen-containing extracellular matrix 생물학적 과정 blood coagulation, intrinsic pathway regulation of blood coagulation positive regulation of phosphatidylinositol 3-kinase signaling positive regulation of collagen biosynthetic process multicellular organism development peptidyl-glutamic acid carboxylation acute-phase response positive regulation of reactive oxygen species metabolic process endoplasmic reticulum to Golgi vesicle-mediated transport positive regulation of cell growth cell surface receptor signaling pathway 유전자 발현의 조절 positive regulation of release of sequestered calcium ion into cytosol positive regulation of cell population proliferation leukocyte migration negative regulation of fibrinolysis positive regulation of blood coagulation regulation of cytosolic calcium ion concentration response to wounding signal peptide processing positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway regulation of cell shape 지혈 negative regulation of proteolysis negative regulation of platelet activation negative regulation of astrocyte differentiation positive regulation of protein phosphorylation fibrinolysis 혈액응고 단백질분해과정 platelet activation positive regulation of protein localization to nucleus positive regulation of lipid kinase activity regulation of complement activation 항미생물 펩타이드에 의해 매개되는 항미생물 체액성 면역 반응 negative regulation of cytokine production involved in inflammatory response 신호전달 수용체 활성의 조절 G protein-coupled receptor signaling pathway positive regulation of receptor signaling pathway via JAK-STAT blood coagulation, fibrin clot formation 출처: Amigo / QuickGO
동원체 종 인간 쥐 앙트레 2147 14061 앙상블 ENSG00000180210 ENSMUSG00000027249 유니프롯 P00734 P19221 RefSeq (mRNA) NM_000506 NM_001311257 NM_010168 RefSeq(단백질) NP_000497 NP_034298 위치(UCSC) Chr 11: 46.72 – 46.74 Mb Chr 2: 91.46 – 91.47 Mb PubMed 검색 [3] [4]
위키데이터
인간 보기/편집 쥐 보기/편집

프로트롬빈

프로트롬빈(prothrombin)은 트롬빈의 전구물질로, 혈청 속에 들어 있는 단백질의 하나. 트롬빈으로 변하여 혈액을 응고시킨다.

프로트롬빈 분해효소

프로트롬빈 분해효소(prothrombin分解酵素)는 혈액 응고에 관여하는 주요 효소. 혈액 응고의 과정 중 칼슘 이온과 혈소판이 존재할 때 프로트롬빈이 트롬빈으로 전환되는 과정을 촉매한다.

프로트롬빈 시간

프로트롬빈시간(prothrombin時間)은 혈액에 칼슘을 집어넣는 경우에 프로트롬빈이 트롬빈으로 변하는 데 걸리는 시간. 이는 혈액 응고 외인성 경로의 이상을 알아볼 수 있는 검사로 활용된다.

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• 항응고제
• 피브린