Deze hits stonden in 2016 op nummer 1 in de Mega Top 50, de hitlijst van de Nederlandse radiozender NPO 3FM.
Meer informatie Datum, Artiest ...
| Datum | Artiest | Titel |
|---|
| 2 januari |  Justin Bieber | Love Yourself |
| 9 januari | Justin Bieber | Love Yourself |
| 16 januari | Justin Bieber | Love Yourself |
| 23 januari |  Lukas Graham | 7 Years |
| 30 januari |    Major Lazer, Nyla & Fuse ODG | Light It Up (Remix) |
| 6 februari | Major Lazer, Nyla & Fuse ODG | Light It Up (Remix) |
| 13 februari | Mike Posner | I Took a Pill in Ibiza (SeeB Remix) |
| 20 februari | Mike Posner | I Took a Pill in Ibiza (SeeB Remix) |
| 27 februari | Mike Posner | I Took a Pill in Ibiza (SeeB Remix) |
| 5 maart |  Rihanna & Drake | Work |
| 12 maart | Mike Posner | I Took a Pill in Ibiza (SeeB Remix) |
| 19 maart | Mike Posner | I Took a Pill in Ibiza (SeeB Remix) |
| 26 maart | Dua Lipa | Be the One |
| 2 april | Dua Lipa | Be the One |
| 9 april | Dua Lipa | Be the One |
| 16 april | Dua Lipa | Be the One |
| 23 april | Fifth Harmony & Ty Dolla Sign | Work from Home |
| 30 april |  Drake, Wizkid & Kyla | One Dance |
| 7 mei | Drake, Wizkid & Kyla | One Dance |
| 14 mei | Drake, Wizkid & Kyla | One Dance |
| 21 mei | Justin Timberlake | Can't Stop the Feeling! |
| 28 mei | Justin Timberlake | Can't Stop the Feeling! |
| 4 juni | Justin Timberlake | Can't Stop the Feeling! |
| 11 juni | Justin Timberlake | Can't Stop the Feeling! |
| 18 juni | Justin Timberlake | Can't Stop the Feeling! |
| 25 juni | Justin Timberlake | Can't Stop the Feeling! |
| 2 juli | Justin Timberlake | Can't Stop the Feeling! |
| 9 juli | Justin Timberlake | Can't Stop the Feeling! |
| 16 juli | Justin Timberlake | Can't Stop the Feeling! |
| 23 juli | Drake, Wizkid & Kyla | One Dance |
| 30 juli | Major Lazer, Justin Bieber & MØ | Cold Water |
| 6 augustus | Major Lazer, Justin Bieber & MØ | Cold Water |
| 13 augustus | Major Lazer, Justin Bieber & MØ | Cold Water |
| 20 augustus | Major Lazer, Justin Bieber & MØ | Cold Water |
| 27 augustus | Major Lazer, Justin Bieber & MØ | Cold Water |
| 3 september | Major Lazer, Justin Bieber & MØ | Cold Water |
| 10 september |  DJ Snake, Justin Bieber | Let Me Love You |
| 17 september | DJ Snake, Justin Bieber | Let Me Love You |
| 24 september | DJ Snake, Justin Bieber | Let Me Love You |
| 1 oktober | DJ Snake, Justin Bieber | Let Me Love You |
| 8 oktober | DJ Snake, Justin Bieber | Let Me Love You |
| 15 oktober | DJ Snake, Justin Bieber | Let Me Love You |
| 22 oktober | DJ Snake, Justin Bieber | Let Me Love You |
| 29 oktober | DJ Snake, Justin Bieber | Let Me Love You |
| 5 november | DJ Snake, Justin Bieber | Let Me Love You |
| 12 november | The Weeknd, Daft Punk | Starboy |
| 19 november | The Weeknd, Daft Punk | Starboy |
| 26 november | The Weeknd, Daft Punk | Starboy |
| 3 december | Clean Bandit, Sean Paul & Anne-Marie | Rockabye |
| 10 december | Clean Bandit, Sean Paul & Anne-Marie | Rockabye |
| 17 december | Clean Bandit, Sean Paul & Anne-Marie | Rockabye |
| 24 december | Clean Bandit, Sean Paul & Anne-Marie | Rockabye |
| 31 december | Clean Bandit, Sean Paul & Anne-Marie | Rockabye |
Sluiten
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Nederland (Top 40)
Vlaanderen (Radio 2 Top 30)
Wallonië
Australië
Duitsland
Finland
Ierland
Italië
Nieuw-Zeeland
Noorwegen
Oostenrijk
Polen
Portugal
Spanje
Zweden
Zwitserland
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