CD14

CD14 (cluster of differentiation 14) é um gene humano.^[1][2] A proteína codificada por este gene é um componente do sistema imune inato.^[3]

Molécula CD14
Renderização baseada em PDB 1WWL.
Estruturas disponíveis PDB Busca de ortólogos: PDBe, RCSB Lista de códigos PDB 4GLP
Identificadores
Símbolo	CD14
IDs externos	OMIM: 158120 MGI: 88318 HomoloGene: 493 GeneCards: CD14 Gene
Ontologia do gene Função molecular •lipopolysaccharide binding •opsonin receptor activity •peptidoglycan receptor activity •lipoteichoic acid binding Componente celular •extracellular region •extracellular space •plasma membrane •cell surface •endosome membrane •anchored to membrane •membrane raft Processo biológico •toll-like receptor signaling pathway •MyD88-dependent toll-like receptor signaling pathway •MyD88-independent toll-like receptor signaling pathway •phagocytosis •apoptotic process •inflammatory response •cell surface receptor signaling pathway •I-kappaB kinase/NF-kappaB cascade •response to heat •positive regulation of tumor necrosis factor production •toll-like receptor 2 signaling pathway •toll-like receptor 3 signaling pathway •toll-like receptor 4 signaling pathway •TRIF-dependent toll-like receptor signaling pathway •toll-like receptor TLR1:TLR2 signaling pathway •toll-like receptor TLR6:TLR2 signaling pathway •innate immune response •positive regulation of endocytosis •positive regulation of cytokine secretion •cellular response to lipopolysaccharide •cellular response to lipoteichoic acid Sources: Amigo / QuickGO
Padrões de expressão do ARN
Mais dados de expressão
Ortólogos
Espécies	Humano	Rato
Entrez	929	12475
Ensembl	ENSG00000170458	ENSMUSG00000051439
UniProt	P08571	P10810
RefSeq (mRNA)	NM_000591	NM_009841
RefSeq (proteína)	NP_000582	NP_033971
Localização (UCSC)	Chr 5: 140.01 – 140.01 Mb	Chr 18: 36.73 – 36.73 Mb
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Referências

1. Setoguchi M, Nasu N, Yoshida S, Higuchi Y, Akizuki S, Yamamoto S (Julho de 1989). «Mouse and human CD14 (myeloid cell-specific leucine-rich glycoprotein) primary structure deduced from cDNA clones». Biochim. Biophys. Acta. 1008 (2): 213–22. PMID 2472171. doi:10.1016/0167-4781(80)90012-3 !CS1 manut: Nomes múltiplos: lista de autores (link)
2. Simmons DL, Tan S, Tenen DG, Nicholson-Weller A, Seed B (1 de janeiro de 1989). «Monocyte antigen CD14 is a phospholipid anchored membrane protein». Blood. 73 (1): 284–9. PMID 2462937 !CS1 manut: Nomes múltiplos: lista de autores (link)
3. Kirkland TN, Viriyakosol S (1998). «Structure-function analysis of soluble and membrane-bound CD14». Prog. Clin. Biol. Res. 397: 79–87. PMID 9575549

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