Эндотелиальная синтаза оксида азота

Nitric oxide synthase 3 (endothelial cell)
Nitric oxide synthase 3 (endothelial cell)
	Rendering of 1M9J
Доступные структуры
PDB	Поиск ортологов: PDBe, RCSB
	Список идентификаторов PDB 1M9J, 1M9K, 1M9M, 1M9Q, 1M9R, 1NIW, 2LL7, 2MG5, 3EAH, 3NOS, 4D1O, 4D1P
Идентификаторы
Символ	NOS3 ; ECNOS; eNOS
Внешние ID	OMIM: 163729 MGI: 97362 HomoloGene: 504 ChEMBL: 4803 GeneCards: Ген NOS3
номер EC	1.14.13.39
Функция	• actin monomer binding; • NADPH-hemoprotein reductase activity; • nitric-oxide synthase activity; • iron ion binding; • protein binding; • calmodulin binding; • FMN binding; • heme binding; • tetrahydrobiopterin binding; • arginine binding; • cadmium ion binding; • flavin adenine dinucleotide binding; • NADP binding; • scaffold protein binding;
Компонент клетки	• Golgi membrane; • nucleus; • cytoplasm; • cytosol; • cytoskeleton; • plasma membrane; • caveola; • endocytic vesicle membrane;
Биологический процесс	• angiogenesis; • ovulation from ovarian follicle; • in utero embryonic development; • blood vessel remodeling; • regulation of sodium ion transport; • regulation of the force of heart contraction by chemical signal; • regulation of systemic arterial blood pressure by endothelin; • arginine catabolic process; • nitric oxide biosynthetic process; • mitochondrion organization; • nitric oxide mediated signal transduction; • blood coagulation; • regulation of blood pressure; • negative regulation of cell proliferation; • response to heat; • negative regulation of platelet activation; • negative regulation of muscle hyperplasia; • smooth muscle hyperplasia; • removal of superoxide radicals; • lung development; • positive regulation of guanylate cyclase activity; • lipopolysaccharide-mediated signaling pathway; • response to fluid shear stress; • negative regulation of potassium ion transport; • endothelial cell migration; • small molecule metabolic process; • positive regulation of angiogenesis; • negative regulation of blood pressure; • positive regulation of vasodilation; • nitric oxide metabolic process; • vascular endothelial growth factor receptor signaling pathway; • regulation of blood vessel size; • regulation of nitric-oxide synthase activity; • negative regulation of hydrolase activity; • interaction with host; • negative regulation of calcium ion transport; • oxidation-reduction process; • phagosome maturation; • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;
	Источники: Amigo / QuickGO
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Ортологи

Эндотелиальная синтаза оксида азота (eNOS) — одна из NO-синтаз человека, кодируемая геном NOS3 на 7-й хромосоме. Фермент eNOS и ген NOS3 были описаны в 1992-1993 годах.^[1]^[2]^[3]

Краткие факты Nitric oxide synthase 3 (endothelial cell), Доступные структуры ...

Синтезируя NO в кровеносных сосудах, NOS3 влияет на их работу.

[1]

[2]

[3]

Эндотелиальная синтаза оксида азота

Примечания

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