Amphetamine (pronunciation: 
i; contractit frae alpha‑methylphenethylamine) is a potent central nervous seestem (CNS) stimulant o the phenethylamine class that is uised in the treatment o attention deficit hyperacteevity disorder (ADHD) an narcolepsy.
Quick facts Clinical data, AHFS/Drugs.com ...
Amphetamine |
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| Clinical data |
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| AHFS/Drugs.com | entry |
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| Leecence data |
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Pregnancy
category |
- US: C (Risk nae ruled oot)
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Dependence
liability | Pheesical: none
Psychological: moderate |
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Addiction
liability | Moderate |
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Routes o
admeenistration | Medical: oral, nasal inhalation
Recreational: oral, nasal inhalation, insufflation, rectal, intravenous |
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| ATC code | |
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| Legal status |
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| Legal status |
- AU: S8 (Controlled)
- CA: Schedule I
- UK: Class B
- US: Schedule II
- UN: Psychotropic Schedule II
- Rx-anly
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| Pharmacokinetic data |
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| Bioavailability | Rectal 95–100%; Oral 75–100%[1] |
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| Protein bindin | 15–40%[2] |
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| Metabolism | CYP2D6,[3] DBH,[4][5][6] FMO3,[7][8] XM-ligase,[9] an ACGNAT[10] |
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| Onset o action | Immediate |
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| Biological hauf-life | D-amph:9–11h;[3][11] L-amph:11–14h[3][11] |
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| Excretion | Renal; pH-dependent range: 1–75%[3] |
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| Identifiers |
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IUPAC name
- (RS)-1-phenylpropan-2-amine
(RS)-1-phenyl-2-aminopropane
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| Synonyms | α-methylphenethylamine |
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| CAS Nummer | |
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| PubChem CID | |
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| IUPHAR/BPS | |
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| DrugBank | |
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| ChemSpider | |
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| UNII | |
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| KEGG | |
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| ChEBI | |
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| ChEMBL | |
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| NIAID ChemDB | |
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| PDB ligand | |
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| ECHA InfoCard | 100.005.543 |
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| Chemical and physical data |
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| Formula | C9H13N |
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| Molar mass | 135.2084 g/mol |
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| 3D model (Jmol) | |
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| Density | 0.9±0.1 g/cm3 |
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| Meltin pynt | 11.3 °C (52.3 °F) [12] |
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| Bylin pynt | 203 °C (397 °F) [13] |
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InChI=1S/C9H13N/c1-8(10)7-9-5-3-2-4-6-9/h2-6,8H,7,10H2,1H3 Y Key:KWTSXDURSIMDCE-UHFFFAOYSA-N Y
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Close
i/æmˈfɛtəmiːn/; contractit frae alpha‑methylphenethylamine) is a potent central nervous seestem (CNS) stimulant o the phenethylamine class that is uised in the treatment o attention deficit hyperacteevity disorder (ADHD) an narcolepsy.