Cortisone

Cortisone
Names
	IUPAC name (8S,9S,10R,13S,14S,17R)-17-Hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11-dione
	Other names 17α,21-Dihydroxypregn-4-ene-3,11,20-trione; 17α,21-Dihydroxy-11-ketoprogesterone; 17α-Hydroxy-11-dehydrocorticosterone
Identifiers
CAS Number	53-06-5 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:16962 ;
ChEMBL	ChEMBL111861 ;
ChemSpider	193441 ;
ECHA InfoCard	100.000.149
IUPHAR/BPS	5171;
KEGG	D07749 ;
MeSH	Cortisone
PubChem CID	222786;
CompTox Dashboard (EPA)	DTXSID5022857 ;
	SMILES O=C(CO)[C@@]3(O)CC[C@H]2[C@@H]4CC\C1=C\C(=O)CC[C@]1(C)[C@H]4C(=O)C[C@@]23C;
Properties
Chemical formula	C21H28O5
Molar mass	360.45 g·mol−1
Melting point	220 to 224 °C (428 to 435 °F; 493 to 497 K)
Pharmacology
ATC code	H02AB10 (WHO) S01BA03 (WHO)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

Cortisone is a 21-carbon steroid hormone. Its chemical name is 17-hydroxy-11-dehydrocorticosterone. It is one of the main hormones released by the adrenal gland in response to stress.

Quick facts Names, Identifiers ...

In chemical structure, it is closely related to cortisol. It is used to treat a variety of ailments and can be administered in various ways. Cortisone suppresses the immune system. This reduces inflammation, pain and swelling at the site of the injury. Long-term use of cortisone has risks.^[1]^[2]

Tadeus Reichstein, E.C. Kendall and P.S. Hench were awarded the Nobel Prize in Physiology or Medicine in 1950, for their discovery of cortisone.

[1]

[2]

Cortisone

References

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