Dimethyltryptamine (DMT), also known as N,N-dimethyltryptamine (N,N-DMT), is a psychedelic drug from the tryptamine family that is found in nature in many plants and animals.[1][2][3][9] DMT is used as a recreational drug and for spiritual reasons.[10]
Quick facts Clinical data, Other names ...
Dimethyltryptamine |
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| Other names | Dimethyltryptamine; DMT; N,N-DMT |
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Routes of
administration | By mouth (usually with an MAOI), inhalation, insufflation, rectal, intramuscular, intravenous[1][2][3][4] |
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| Drug class | Serotonergic psychedelic (hallucinogen)[1][2][4] |
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| Source tissues | Central nervous system (exact source tissues are not fully established) |
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| Target tissues | Central nervous system |
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| Receptors | At least 13 receptors (e.g., serotonin, sigma, trace amine-associated) |
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| Precursor | Tryptophan |
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| Metabolism | Oxidative deamination (MAO-A), N-oxidation, N-demethylation, peroxidation[1][2] |
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| Legal status |
- AU: S9 (Prohibited substance)
- BR: F2 [5]
- CA: Schedule III
- DE: Anlage I (Authorized scientific use only)
- UK: Class A
- US: Schedule I
- UN: Psychotropic Schedule I
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| Bioavailability | Very low and inactive (except with an MAOI)[4] |
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| Metabolism | Oxidative deamination (MAO-A), N-oxidation, N-demethylation, peroxidation[1][2] |
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| Metabolites |
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| Onset of action |
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| Elimination half-life |
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| Duration of action |
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| Excretion | Urine[4] |
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2-(1H-Indol-3-yl)-N,N-dimethylethanamine
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| ECHA InfoCard | 100.000.463 |
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| Formula | C12H16N2 |
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| Molar mass | 188.27 g·mol−1 |
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| 3D model (JSmol) | |
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| Density | 1.099 g/cm3 |
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| Melting point | 40 °C (104 °F) |
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| Boiling point | 160 °C (320 °F) at 0.6 Torr (80 Pa)[7]
also reported as
80–135 °C (176–275 °F) at 0.03 Torr (4.0 Pa)[8] |
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InChI=1S/C12H16N2/c1-14(2)8-7-10-9-13-12-6-4-3-5-11(10)12/h3-6,9,13H,7-8H2,1-2H3 Y Key:DMULVCHRPCFFGV-UHFFFAOYSA-N Y
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Close
DMT works very quickly, has strong hallucinogenic effects, and works for only a few minutes. These reasons mean people in jobs such as businesspeople are known to use it.[11] DMT can be inhaled or injected and its effects are different with different amounts used or different ways of taking it. When inhaled or injected, the effects last about five to fifteen minutes. Effects can last three hours or more when swallowed with a monoamine oxidase inhibitor (MAOI), such as ayahuasca used by Amazonian tribes.[12] DMT causes effects that are hard to describe with words, such as very complex visual hallucinations (seeing things that are not there), changes to senses, ego death. DMT is is not addictive but can cause issues for the heart.
