Lithium bis(trimethylsilyl)amide
chemical compound From Wikipedia, the free encyclopedia
Remove ads
Lithium bis(trimethylsilyl)amide is a lithiated organosilicon compound. Its chemical formula is LiN(SiMe3)2. It is commonly abbreviated as LiHMDS which means lithium hexamethyldisilazide. It is mainly used as a strong non-nucleophilic base and as a ligand.
Preparation
It can be made by the deprotonation of bis(trimethylsilyl)amine with n-butyllithium.[1] Once its made, the compound can be purified by sublimation or distillation.
Uses
It is often used in organic chemistry as a strong non-nucleophilic base.[2] It can be used to make many organolithium compounds, including acetylides or lithium enolates.[2][3]
References
Wikiwand - on
Seamless Wikipedia browsing. On steroids.
Remove ads