Paul Modrich

Paul Lawrence Modrich (born June 13, 1946) is an American biochemist. He is known for his research on DNA mismatch repair. He received the Nobel Prize in Chemistry 2015, together with Aziz Sancar and Tomas Lindahl.^[1][2]

Paul L. Modrich
Paul L. Modrich, Nobel Laureate in chemistry in Stockholm December 2015
Born	Paul Lawrence Modrich (1946-06-13) June 13, 1946 (age 79) Raton, New Mexico, U.S.
Nationality	United States
Alma mater	MIT, Stanford University (PhD)
Known for	Clarification of cellular resistance to carcinogens
Awards	Nobel Prize in Chemistry (2015)
Scientific career
Fields	DNA mismatch repair
Institutions	Duke University Howard Hughes Medical Institute University of California, Berkeley
Website	Paul L. Modrich

He was born on June 13, 1946, in Raton, New Mexico to Laurence and Margaret Modrich. He has a younger brother Dave. His father was a biology teacher and coach for basketball, football and tennis at Raton High School where he graduated in 1964.

His work

He works primarily on strand-directed mismatch repair. His lab demonstrated how DNA mismatch repair serves as a copyeditor to prevent errors from DNA polymerase. Matthew Meselson previously proposed the existence of recognition of mismatches. Modrich performed biochemical experiments to study mismatch repair in E. coli.^[3] They later searched for proteins associated with mismatch repair in humans.^[4]