Pronunciation (UK) IPA (key): /dɪˈspɛə(r)/ (US) IPA (key): /dɪˈspɛər/ Audio (US)(file) Hyphenation: des‧pair Noun Singular despair Plural despairs (countable & uncountable) Despair is the opposite of hope. Synonym: hopelessness Antonym: hopeWikiwand - on Seamless Wikipedia browsing. On steroids.Remove ads