Pronunciation enPR: sĕt'ŭp', IPA (key): /ˈsɛtʌp/ Audio (UK)(file) Noun Singular setup Plural setups A setup is an equipment that is designed for a specific use. A setup is a scheme or trick that is used to deceive or frame someone. Listen. He didn't die. It was a set-up A setup is the way in which something is organized or arranged. The classroom setup was simple and efficient.Wikiwand - on Seamless Wikipedia browsing. On steroids.Remove ads