Nitrogenaza

Nitrogenaza (EC 1.18.6.1, Nitrogenase) je enzim sa sistematskim imenom redukovani feredoksin:dinitrogen oksidoreduktaza (ATP-hidroliza).^[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

8 redukovani feredoksin + 8 ⁺ + ₂ + 16 ATP + 16₂O ${\displaystyle \rightleftharpoons }$ 8 oksidovani feredoksin + ₂ + 2 ₃ + 16 ADP + 16 fosfat

Nitrogenaza
Identifikatori
EC broj	1.18.6.1
CAS broj	2598062
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC članci PubMed članci NCBI proteini

Za dejstvo ovog enzim je neohodan ²⁺. On se sastoji od dva proteina. Oni se mogu razdvojiti. Oba proteina su neophodna za nitrogenazno dejstvo.

Reference

1. Zumft, W.G., Paneque, A., Aparicio, P.J. and Losada, M. (1969). „Mechanism of nitrate reduction in Chlorella”. Biochem. Biophys. Res. Commun. 36: 980—986. PMID 4390523.CS1 одржавање: Вишеструка имена: списак аутора (веза)
2. Liang, J. & Burris, R.H. (1988). „Hydrogen burst associated with nitrogenase-catalyzed reactions”. Proc. Natl. Acad. Sci. USA. 85: 9446—9450. PMID 3200830.
3. Dance, I. (2004). „The mechanism of nitrogenase. Computed details of the site and geometry of binding of alkyne and alkene substrates and intermediates”. J. Am. Chem. Soc. 126: 11852—11863. PMID 15382920.
4. Chan, J.M., Wu, W., Dean, D.R. and Seefeldt, L.C. (2000). „Construction and characterization of a heterodimeric iron protein: defining roles for adenosine triphosphate in nitrogenase catalysis”. Biochemistry. 39: 7221—7228. PMID 10852721.CS1 одржавање: Вишеструка имена: списак аутора (веза)

Literatura

• Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
• Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
• William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

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