EGR2

早期生长反应蛋白2（英语：Early growth response protein 2，EGR-2）是一个由人类基因EGR2编码的蛋白质。

早期生长应答蛋白2 Early growth response 2
PDB rendering based on 1a1i.
有效结构 PDB 直系同源检索：PDBe, RCSB PDB查询代码列表 1a1i​, 1a1j​, 1a1k​, 1a1l​, 1aay​, 1jk1​, 1jk2​, 1p47​, 1zaa​
标识
代号	EGR2; AT591; CMT1D; CMT4E; KROX20
扩展标识	遗传学：129010 鼠基因：95296 同源基因：20123 GeneCards: EGR2 Gene
基因本体论描述 分子功能 · RNA polymerase II activating transcription factor binding · chromatin binding · sequence-specific DNA binding transcription factor activity · protein binding · zinc ion binding · ligase activity · ubiquitin protein ligase binding · transcription regulatory region DNA binding · HMG box domain binding 细胞成分 · nucleus · cytoplasm 生物过程 · transcription from RNA polymerase II promoter · protein export from nucleus · brain development · peripheral nervous system development · learning or memory · rhythmic behavior · motor neuron axon guidance · Schwann cell differentiation · protein sumoylation · facial nerve structural organization · rhombomere 3 formation · rhombomere 5 formation · regulation of ossification · response to insulin stimulus · brain segmentation · myelination · fat cell differentiation · positive regulation of transcription, DNA-dependent · positive regulation of transcription from RNA polymerase II promoter · regulation of neuronal synaptic plasticity · cellular response to organic substance Sources: Amigo / QuickGO
RNA表达模式
更多表达数据
直系同源体
物种	人类	小鼠
Entrez	1959	13654
Ensembl	ENSG00000122877	ENSMUSG00000037868
UniProt	P11161	P08152
mRNA序列	NM_000399	NM_010118
蛋白序列	NP_000390	NP_034248
基因位置	Chr 10: 64.57 – 64.68 Mb	Chr 10: 67.54 – 67.54 Mb
PubMed查询	[1]	[2]
查 论 编

EGR2是一个转录因子，包含三个串联的Cys2His2型锌指结构，该基因的多态性与I型进行性神经性腓骨肌萎缩症有关^[1]。