CD132

CD132，又称为共用γ链（Common gamma chain，缩写γ_c)，白介素2受体γ亚基（interleukin-2 receptor subunit gamma，缩写IL-2RG）是一种细胞因子受体亚基，存在于至少六种不同的白介素受体中：包括IL-2、IL-4^[7]、IL-7^[8]、IL-9、IL-15^[9]和IL-21的受体。γ_c是I型细胞因子受体家族中的一种糖蛋白，表达于大部分的淋巴细胞群体，哺乳动物的此基因位于X染色体。

CD132
已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 2B5I、​2ERJ、​3BPL、​3QAZ、​3QB7、​4GS7
识别号
别名	IL2RG；, CD132, CIDX, IL-2RG, IMD4, P64, SCIDX, SCIDX1, interleukin 2 receptor subunit gamma
外部ID	OMIM：308380 MGI：96551 HomoloGene：172 GeneCards：IL2RG
相关疾病
X性联严重复合免疫缺乏症、​combined immunodeficiency, X-linked[1]
为以下药物的标靶
denileukin diftitox[2]
基因位置（人类） 染色体 X染色体[3] 基因座 Xq13.1 起始 71,107,404 bp[3] 终止 71,112,108 bp[3]
基因位置（小鼠） 染色体 小鼠X染色体[4] 基因座 X D|X 43.9 cM 起始 100,307,984 bp[4] 终止 100,311,861 bp[4]
RNA表达模式
查阅更多表达数据
基因本体 分子功能 • interleukin-7 receptor activity • interleukin-2 receptor activity • 血浆蛋白结合 • cytokine receptor activity • interleukin-4 receptor activity • interleukin-2 binding • cytokine binding • interleukin-15 receptor activity 细胞组分 • integral component of membrane • 膜 • 细胞膜 • integral component of plasma membrane • external side of plasma membrane • 核内体 • 细胞质基质 • cell surface • receptor complex 生物学过程 • MAPK cascade • 免疫反应 • viral process • 信号转导 • interleukin-2-mediated signaling pathway • interleukin-4-mediated signaling pathway • interleukin-7-mediated signaling pathway • interleukin-15-mediated signaling pathway • interleukin-9-mediated signaling pathway • 分子功能调控 • cytokine-mediated signaling pathway • interleukin-21-mediated signaling pathway • positive regulation of phagocytosis Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	3561	16186
Ensembl	ENSG00000147168	ENSMUSG00000031304
UniProt	P31785	P34902
mRNA​序列	NM_000206	NM_013563 ​NM_001308535
蛋白序列	NP_000197	NP_001295464 ​NP_038591
基因位置​（UCSC）	Chr X: 71.11 – 71.11 Mb	Chr X: 100.31 – 100.31 Mb
PubMed​查找	[5]	[6]
维基数据
查看/编辑人类 查看/编辑小鼠

参考文献

1. 與CD132相關的疾病；在維基數據上查看/編輯參考.
2. 對Interleukin 2 receptor subunit gamma起作用的藥物；在維基數據上查看/編輯參考.
3. GRCh38: Ensembl release 89: ENSG00000147168 - Ensembl, May 2017
4. GRCm38: Ensembl release 89: ENSMUSG00000031304 - Ensembl, May 2017
5. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
6. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
7. Russell SM, Keegan AD, Harada N, Nakamura Y, Noguchi M, Leland P, Friedmann MC, Miyajima A, Puri RK, Paul WE. Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science. December 1993, 262 (5141): 1880–3. PMID 8266078. doi:10.1126/science.8266078.
8. Noguchi M, Nakamura Y, Russell SM, Ziegler SF, Tsang M, Cao X, Leonard WJ. Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor. Science. December 1993, 262 (5141): 1877–80. PMID 8266077. doi:10.1126/science.8266077.
9. Giri JG, Kumaki S, Ahdieh M, Friend DJ, Loomis A, Shanebeck K, DuBose R, Cosman D, Park LS, Anderson DM. Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor. EMBO J. August 1995, 14 (15): 3654–63. PMC 394440 . PMID 7641685.

延伸阅读

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外部链接

• 医学主题词表（MeSH）：Interleukin+Receptor+Common+gamma+Subunit