Pho4

Pho4是一种在酿酒酵母（S. cerevisiae）中发现的碱性螺旋-环-螺旋（bHLH）转录因子，在其它酵母中也有发现^[2]

Pho4
Crystallographic structure of yeast Pho4 homodimer (cyan and green) complexed with DNA (brown).[1]
标识
生物	?
符号	Pho4
可选符号	YFR034C
Entrez	850594
PDB	1a0a
UniProt	P07270
其他数据

Pho4蛋白形成同源二聚体后进入细胞核结合DNA，其识别位点为：5'-CACGTG-3'^[3]，这一序列常出现在Pho5等磷酸酶基因的启动子区域^[4]。

参考文献

1. PDB 1a0a; Shimizu T, Toumoto A, Ihara K, Shimizu M, Kyogoku Y, Ogawa N, Oshima Y, Hakoshima T. Crystal structure of PHO4 bHLH domain-DNA complex: flanking base recognition. EMBO J. August 1997, 16 (15): 4689–97. PMC 1170095 . PMID 9303313. doi:10.1093/emboj/16.15.4689.
2. Berben G, Legrain M, Gilliquet V, Hilger F. The yeast regulatory gene PHO4 encodes a helix-loop-helix motif. Yeast. 1990, 6 (5): 451–4. PMID 2220078. doi:10.1002/yea.320060510.
3. Shao D, Creasy CL, Bergman LW. A cysteine residue in helixII of the bHLH domain is essential for homodimerization of the yeast transcription factor Pho4p. Nucleic Acids Res. February 1998, 26 (3): 710–4. PMC 147311 . PMID 9443961. doi:10.1093/nar/26.3.710.
4. Ogawa N, Oshima Y. Functional domains of a positive regulatory protein, PHO4, for transcriptional control of the phosphatase regulon in Saccharomyces cerevisiae. Mol. Cell. Biol. May 1990, 10 (5): 2224–36. PMC 360570 . PMID 2183025. doi:10.1128/mcb.10.5.2224.

外部链接

• 医学主题词表（MeSH）：PHO4+protein,+S+cerevisiae