腎上腺素受體α1A

腎上腺素受體α1A
識別號
別名	ADRA1A；, ADRA1C, ADRA1L1, ALPHA1AAR, adrenoceptor alpha 1A
外部ID	OMIM：104221 MGI：104773 HomoloGene：68078 GeneCards：ADRA1A
為以下藥物的標靶
	腎上腺素、甲氧明、正腎上腺素、羥甲唑啉、脫羥腎上腺素、地西泮、阿夫唑嗪、BMY-7378、過乳降、氯氮平、希普利敏、可迅、indoramin、酮色林、麥角乙脲、米塞林、NAN 190、苄胺唑啉、吡貝地爾、利培酮、ritanserin、roxindole、賽洛多辛、spiperone、spiroxatrine、坦索羅辛、定脈平、特麥角脲、WB-4101、哌唯嗪、異蘇胺酸、腎上腺素、正腎上腺素、麻黃鹼、methoxamine hydrochloride、dabuzalgron、dipivefrin hydrochloride、多沙唑嗪甲磺酸鹽、oxymetazoline hydrochloride、phenoxybenzamine hydrochloride、phenylephrine hydrochloride、prazosin hydrochloride、tamsulosin hydrochloride、midodrine hydrochloride、alfuzosin hydrochloride
基因位置（人類）
染色體	8號染色體
終止	26,867,278 bp
基因位置（小鼠）
染色體	小鼠14號染色體
終止	67,008,617 bp
RNA表現模式
	; ; ; ;
	查閱更多表現資料
基因本體
分子功能	• signal transducer activity; • adrenergic receptor activity; • protein heterodimerization activity; • G protein-coupled receptor activity; • alpha1-adrenergic receptor activity; • 血漿蛋白結合;
細胞組分	• 橫小管; • 核膜; • integral component of membrane; • 細胞核; • integral component of plasma membrane; • 膜; • Z discdkac; • 細胞膜; • 細胞質; • caveola; • dopaminergic synapse; • glutamatergic synapse; • GABA-ergic synapse; • integral component of postsynaptic membrane; • integral component of presynaptic membrane;
生物學過程	• positive regulation of cardiac muscle contraction; • negative regulation of cell population proliferation; • response to hormone; • norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure; • positive regulation of MAPK cascade; • intracellular signal transduction; • positive regulation of ERK1 and ERK2 cascade; • 訊息傳遞; • organ growth; • cell-cell signaling; • positive regulation of smooth muscle contraction; • activation of phospholipase C activity; • pilomotor reflex; • regulation of vasoconstriction; • positive regulation of heart rate; • positive regulation of synaptic transmission, GABAergic; • positive regulation of systemic arterial blood pressure; • G protein-coupled receptor signaling pathway; • 排尿; • calcium ion transport into cytosol; • positive regulation of action potential; • positive regulation of the force of heart contraction by epinephrine-norepinephrine; • 細胞凋亡; • 平滑肌收縮; • phospholipase C-activating G protein-coupled receptor signaling pathway; • adenylate cyclase-activating adrenergic receptor signaling pathway; • 老化; • regulation of cardiac muscle contraction; • positive regulation of heart rate by epinephrine-norepinephrine; • positive regulation of protein kinase C signaling; • negative regulation of Rho protein signal transduction; • regulation of muscle contraction; • adult heart development; • negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure; • positive regulation of cytosolic calcium ion concentration; • positive regulation of vasoconstriction; • negative regulation of autophagy; • positive regulation of cardiac muscle hypertrophy; • positive regulation of non-membrane spanning protein tyrosine kinase activity; • cell growth involved in cardiac muscle cell development; • regulation of synaptic vesicle exocytosis; • adenylate cyclase-modulating G protein-coupled receptor signaling pathway; • neuron-glial cell signaling;
	Sources:Amigo / QuickGO
直系同源
	148
	11549
	ENSG00000120907
	ENSMUSG00000045875
	P35348
	P97718
NM_000680; NM_033302; NM_033303; NM_033304; NM_001322502;
	NM_001322503; NM_001322504
	NM_001271759; NM_001271760; NM_001271761; NM_013461
NP_000671; NP_001309431; NP_001309432; NP_001309433; NP_150645;
	NP_150646; NP_150647
	NP_001258688; NP_001258689; NP_001258690; NP_038489
	維基資料
檢視/編輯人類	檢視/編輯小鼠

腎上腺素受體α_1A（α_1A adrenoreceptor），又稱為ADRA1A^[6]，是一種α1腎上腺素受體（英語：alpha-1 adrenergic receptor）^[7]。過去一度有α_1C的分類，但在研究後認為α_1C僅是α_1A的一種亞型，因此取消該命名。為了避免混淆，之後新發現的亞型便從D開始繼續命名。