TRAF6

TRAF6是人類基因 TRAF6 編碼的蛋白質，屬於一種TNF受體相關因子（TRAF）。

TRAF6
已知的結構 PDB 直系同源搜尋: PDBe RCSB PDBID列表 1LB4、​1LB5、​1LB6、​2ECI、​2JMD、​3HCS、​3HCT、​3HCU、​4Z8M
識別號
別名	TRAF6；, MGC:3310, RNF85, TNF receptor associated factor 6
外部ID	OMIM：602355 MGI：108072 HomoloGene：3395 GeneCards：TRAF6
基因位置（人類） 染色體 11號染色體[1] 基因座 11p12 起始 36,483,769 bp[1] 終止 36,510,272 bp[1]
基因位置（小鼠） 染色體 小鼠2號染色體[2] 基因座 2|2 E2 起始 101,508,774 bp[2] 終止 101,532,014 bp[2]
RNA表現模式
查閱更多表現資料
基因本體 分子功能 • protein N-terminus binding • histone deacetylase binding • ubiquitin protein ligase activity • 金屬離子結合 • mitogen-activated protein kinase kinase kinase binding • 鋅離子結合 • 血漿蛋白結合 • thioesterase binding • ubiquitin conjugating enzyme binding • protein kinase binding • protein kinase B binding • 泛素蛋白轉移酶活性 • 相同蛋白質結合 • 泛素蛋白連接酶結合 • 轉移酶活性 • tumor necrosis factor receptor binding 細胞組分 • 細胞質 • 細胞質基質 • 脂滴 • 細胞質的核周區域 • cytoplasmic side of plasma membrane • 細胞核 • 細胞膜 • 細胞皮層 • endosome membrane • CD40 receptor complex • 大分子複合體 生物學過程 • positive regulation of transcription regulatory region DNA binding • response to interleukin-1 • toll-like receptor signaling pathway • Fc-epsilon receptor signaling pathway • odontogenesis of dentin-containing tooth • animal organ morphogenesis • T-helper 1 type immune response • toll-like receptor 9 signaling pathway • regulation of apoptotic process • 成骨作用 • cytokine-mediated signaling pathway • osteoclast differentiation • positive regulation of osteoclast differentiation • stimulatory C-type lectin receptor signaling pathway • activation of NF-kappaB-inducing kinase activity • 骨質吸收 • JNK cascade • membrane protein intracellular domain proteolysis • protein ubiquitination • positive regulation of T cell proliferation • I-kappaB kinase/NF-kappaB signaling • protein autoubiquitination • immune system process • positive regulation of JUN kinase activity • positive regulation of DNA-binding transcription factor activity • protein polyubiquitination • negative regulation of apoptotic process • negative regulation of transcription by RNA polymerase II • positive regulation of lipopolysaccharide-mediated signaling pathway • positive regulation of NF-kappaB transcription factor activity • positive regulation of interleukin-2 production • positive regulation of T cell cytokine production • 免疫反應 • negative regulation of transcription, DNA-templated • 含有信號通路的核苷酸結合寡聚結構域 • positive regulation of protein ubiquitination • positive regulation of smooth muscle cell proliferation • antigen processing and presentation of exogenous peptide antigen via MHC class II • cell development • protein K63-linked ubiquitination • myeloid dendritic cell differentiation • MyD88-dependent toll-like receptor signaling pathway • neural tube closure • 骨的再建 • positive regulation of apoptotic process • positive regulation of I-kappaB kinase/NF-kappaB signaling • cellular response to lipopolysaccharide • T cell receptor signaling pathway • activation of protein kinase activity • positive regulation of transcription by RNA polymerase II • 訊息傳遞 • cellular response to DNA damage stimulus • protein deubiquitination • regulation of I-kappaB kinase/NF-kappaB signaling • interleukin-1-mediated signaling pathway • cellular response to cytokine stimulus • positive regulation of NIK/NF-kappaB signaling • positive regulation of leukocyte adhesion to vascular endothelial cell Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	7189	22034
Ensembl	ENSG00000175104	ENSMUSG00000027164
UniProt	Q9Y4K3	P70196
mRNA​序列	NM_145803 ​NM_004620	NM_009424 ​NM_001303273
蛋白序列	NP_004611 ​NP_665802	NP_001290202 ​NP_033450
基因位置​（UCSC）	Chr 11: 36.48 – 36.51 Mb	Chr 2: 101.51 – 101.53 Mb
PubMed​查找	[3]	[4]
維基資料
檢視/編輯人類 檢視/編輯小鼠

蛋白質的相互作用

TRAF6蛋白與下列蛋白質進行互作：

• ASK1^[5][6][7]
• CD40^[8][9]
• FHL2^[10]
• HSPB2^[11]
• IKBKG^[12][13]
• IRAK1^{[14][15][16][17][18][19][20][21][22]}
• IRAK2^[15][16]
• TAB1^[23][24][25]
• MAP3K7IP2^{[12][22][23][24][26][27]}
• MAP3K7^{[7][22][23][24][25][26][28]}
• PPP4C^[29]
• RANK^{[30][31][32][33][34]}
• SDCBP^[14]
• SIGIRR^[35]
• Sequestosome 1^[36]
• TAX1BP1^[21]
• TNFAIP3^[37][38]
• TNFRSF13B^[39]
• UBE2N^[40]
• Ubiquitin C^{[13][27][29][41][42]}