低密度脂蛋白受體

低密度脂蛋白受體
低密度脂蛋白受體
	PDB rendering based on 1ajj.
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	1AJJ, 1D2J, 1F5Y, 1F8Z, 1HJ7, 1HZ8, 1I0U, 1IJQ, 1LDL, 1LDR, 1LRX, 1N7D, 1XFE, 2FCW, 2KRI, 2LGP, 2M7P, 2MG9, 2W2M, 2W2N, 2W2O, 2W2P, 2W2Q, 3BPS, 3GCW, 3GCX, 3M0C, 3P5B, 3P5C, 3SO6
标识
代号	LDLR; FH; FHC; LDLCQ2
扩展标识	遗传学：606945 鼠基因：96765 同源基因：55469 ChEMBL: 3311 GeneCards: LDLR Gene
基因本体论描述
分子功能	· glycoprotein binding; · low-density lipoprotein receptor activity; · calcium ion binding; · protein binding; · low-density lipoprotein particle binding; · very-low-density lipoprotein particle receptor activity;
细胞成分	· lysosome; · early endosome; · late endosome; · Golgi apparatus; · plasma membrane; · integral component of plasma membrane; · coated pit; · external side of plasma membrane; · cell surface; · endosome membrane; · membrane; · clathrin-coated endocytic vesicle membrane; · low-density lipoprotein particle; · receptor complex;
生物过程	· retinoid metabolic process; · lipid metabolic process; · endocytosis; · receptor-mediated endocytosis; · phototransduction, visible light; · cholesterol metabolic process; · positive regulation of triglyceride biosynthetic process; · regulation of phosphatidylcholine catabolic process; · phospholipid transport; · viral process; · intestinal cholesterol absorption; · cholesterol transport; · low-density lipoprotein particle clearance; · lipoprotein metabolic process; · lipoprotein catabolic process; · cholesterol homeostasis; · small molecule metabolic process; · cholesterol import;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
物种	人类
Entrez	3949
Ensembl	ENSG00000130164
UniProt	P01130
mRNA序列	NM_000527
蛋白序列	NP_000518
基因位置	Chr 19:; 11.2 – 11.24 Mb
PubMed查询	[1]
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低密度脂蛋白受體（Low-Density Lipoprotein (LDL) Receptor），又稱LDL受體，為一種膜鑲嵌式蛋白質，全長有839個胺基酸（扣掉21胺基酸長的訊息肽）^[1]。本受體調控低密度脂蛋白（LDL）的胞吞作用。此種受體專門辨認LDL顆粒上的B100脂蛋白，也可辨認乳糜微粒殘體及中間密度脂蛋白（IDL，極低密度脂蛋白的殘體）上的Apo E。人體LDL受體的基因編碼為LDLR基因^[2]^[3]。屬於低密度脂蛋白受體家族（英语：Low density lipoprotein receptor gene family）^[4]。