嘌呤核苷磷酸化酶

嘌呤核苷磷酸化酶英語：Purine nucleoside phosphorylase，简写为PNPase)化学式为^[1]：C₁₄₃₅H₂₂₃₇O₄₁₄N₃₉₅S₁₆^[2]是参与嘌呤代谢的一种酶。嘌呤核苷磷酸化酶可以代谢腺苷到腺嘌呤，肌苷到次黄嘌呤，鸟苷到鸟嘌呤，并在这些反应中产生核糖-1-磷酸。

嘌呤核苷磷酸化酶（PNPase）
識別
符號	NP
Entrez	4860
国际人类基因组组织	7892
人類孟德爾遺傳學	164050
蛋白質資料庫	1RT9
UniProt	P00491
其他資料
EC編號	2.4.2.1
基因座	14 q13.1

嘌呤核苷磷酸化酶
PDB rendering based on 1m73.
有效结构 PDB 直系同源检索：PDBe, RCSB PDB查询代码列表 1M73​, 1PF7​, 1PWY​, 1RCT​, 1RFG​, 1RR6​, 1RSZ​, 1RT9​, 1ULA​, 1ULB​, 1V2H​, 1V3Q​, 1V41​, 1V45​, 1YRY​, 2A0W​, 2A0X​, 2A0Y​, 2OC4​, 2OC9​, 2ON6​, 2Q7O​, 3BGS​, 3D1V​, 3GB9​, 3GGS​, 3K8O​, 3K8Q​
标识
代号	PNP; FLJ94043; FLJ97288; FLJ97312; MGC117396; MGC125915; MGC125916; NP; PRO1837; PUNP
扩展标识	遗传学：164050 鼠基因：97365 同源基因：227 GeneCards: PNP Gene
EC編號	2.4.2.1
基因本体论描述 分子功能 · nucleoside binding · purine base binding · purine-nucleoside phosphorylase activity · purine-nucleoside phosphorylase activity · drug binding · phosphate binding 细胞成分 · intracellular · cytoplasm · cytosol · cytoskeleton 生物过程 · nucleobase, nucleoside, nucleotide and nucleic acid metabolic process · purine base metabolic process · inosine catabolic process · purine nucleotide catabolic process · nicotinamide riboside catabolic process · immune response · nucleoside metabolic process · NAD biosynthesis via nicotinamide riboside salvage pathway · urate biosynthetic process · positive regulation of T cell proliferation · response to drug · response to drug · purine-containing compound salvage · positive regulation of alpha-beta T cell differentiation · nucleobase, nucleoside and nucleotide metabolic process · interleukin-2 secretion Sources: Amigo / QuickGO
RNA表达模式
更多表达数据
直系同源体
物种	人类	小鼠
Entrez	4860	18950
Ensembl	ENSG00000198805	ENSMUSG00000021871
UniProt	P00491	P23492
mRNA序列	NM_000270.3	NM_013632.4
蛋白序列	NP_000261.2	NP_038660.1
基因位置	Chr 14: 20.94 – 20.95 Mb	Chr 14: 51.56 – 51.57 Mb
PubMed查询	[1]	[2]
查 论 编

需要注意的是，PNPase这一简称还被用于另一个不相关的酶，多核苷酸磷酸化酶（Polynucleotide Phosphorylase）。

相关疾病

嘌呤核苷磷酸化酶缺陷型病患会有免疫缺陷，而只有免疫系统中的T细胞和B细胞不受此缺陷影响。

参见

• 磷酸化酶

深入阅读

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