ERG ili ETS-srodni gen jest ljudski onkogen sa hromosoma 21.[5][6][7] ERG je član porodice ETS (erythroblast transformation-specific) transkripcijskih faktora.[8] Gen ERG kodira protein, koji se također naziva ERG, koji funkcionira kao regulator transkripcije. Geni u porodici ETS regulišu razvoj embrija, proliferaciju i diferencijaciju ćelija, te angiogenezu, upale i apoptoze.
Kratke činjenice Dostupne strukture, PDB ...
ERG (gen) |
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Identifikatori |
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Aliasi | ERG |
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Vanjski ID-jevi | OMIM: 165080 MGI: 95415 HomoloGene: 15848 GeneCards: ERG |
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Ontologija gena |
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Molekularna funkcija | • DNA binding • sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • chromatin binding • signal transducer activity • GO:0001948, GO:0016582 protein binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
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Ćelijska komponenta | • citoplazma • Jedro • Ribonukleoprotein
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Biološki proces | • Ćelijska diferencijacija • GO:0009373 regulation of transcription, DNA-templated • endocardial cushion development • endocardial cushion to mesenchymal transition involved in heart valve formation • transcription, DNA-templated • multicellular organism development • positive regulation of blood vessel remodeling • protein phosphorylation • Ćelijska proliferacija • Ćelijska migracija • GO:0072468 Transdukcija signala • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II
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Izvori:Amigo / QuickGO |
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Ortolozi |
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Vrste | Čovjek | Miš |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNK) | | |
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RefSeq (bjelančevina) | | |
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Lokacija (UCSC) | Chr 21: 38.38 – 38.66 Mb | Chr 16: 95.16 – 95.39 Mb |
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PubMed pretraga | [3] | [4] |
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Wikipodaci |
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Zatvori