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Chemical compound From Wikipedia, the free encyclopedia
3,4-Dihydroxyphenylacetic acid (DOPAC) is a metabolite of the neurotransmitter dopamine. Dopamine can be metabolized into one of three substances. One such substance is DOPAC. Another is 3-methoxytyramine (3-MT). Both of these substances are degraded to form homovanillic acid (HVA). Both degradations involve the enzymes monoamine oxidase (MAO) and catechol-O-methyl transferase (COMT), albeit in reverse order: MAO catalyzes dopamine to DOPAC, and COMT catalyzes DOPAC to HVA; whereas COMT catalyzes dopamine to 3-MT and MAO catalyzes 3-MT to HVA. The third metabolic end-product of dopamine is norepinephrine (noradrenaline).
Names | |
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Preferred IUPAC name
(3,4-Dihydroxyphenyl)acetic acid | |
Other names
2-(3,4-Dihydroxyphenyl)acetic acid | |
Identifiers | |
3D model (JSmol) |
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ChemSpider | |
DrugBank | |
ECHA InfoCard | 100.002.750 |
KEGG | |
MeSH | 3,4-Dihydroxyphenylacetic+Acid |
PubChem CID |
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UNII | |
CompTox Dashboard (EPA) |
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Properties | |
C8H8O4 | |
Molar mass | 168.148 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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It can also be found in the bark of Eucalyptus globulus.[1]
This product has been synthesized (52% yield) from 4-hydroxyphenylacetic acid via aerobic biotransformation using whole cell cultures of Arthrobacter protophormiae.[2][3]
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