CD6

CD6 (Cluster of Differentiation 6) is a human protein encoded by the CD6 gene.^[5][6]

CD6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5A2E
Identifiers
Aliases	CD6, TP120, CD6 molecule
External IDs	OMIM: 186720; MGI: 103566; HomoloGene: 4893; GeneCards: CD6; OMA:CD6 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q12.2 Start 60,971,680 bp[1] End 61,020,377 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 A|19 7.16 cM Start 10,766,705 bp[2] End 10,807,422 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte lymph node blood thymus appendix spleen cervix epithelium superficial temporal artery bone marrow endothelial cell Top expressed in thymus mesenteric lymph nodes blood granulocyte embryo axillary lymph node subcutaneous adipose tissue embryo spleen morula More reference expression data BioGPS n/a
Gene ontology Molecular function lipopolysaccharide binding lipoteichoic acid binding scavenger receptor activity protein binding identical protein binding Cellular component integral component of membrane membrane intrinsic component of plasma membrane plasma membrane integral component of plasma membrane T cell receptor complex extracellular region immunological synapse external side of plasma membrane Biological process positive regulation of cytokine production involved in inflammatory response heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules adaptive immune response immune system process acute inflammatory response to antigenic stimulus receptor-mediated endocytosis response to lipopolysaccharide cell adhesion positive regulation of T cell proliferation innate immune response immunological synapse formation lipopolysaccharide-mediated signaling pathway vesicle-mediated transport endocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 923 12511 Ensembl ENSG00000013725 ENSMUSG00000024670 UniProt P30203 Q61003 RefSeq (mRNA) NM_001254750 NM_001254751 NM_006725 NM_001037801 NM_009852 RefSeq (protein) NP_001241679 NP_001241680 NP_006716 NP_001032890 NP_033982 Location (UCSC) Chr 11: 60.97 – 61.02 Mb Chr 19: 10.77 – 10.81 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation.^[5]

Clinical significance

Certain alleles of this gene may be associated with susceptibility to multiple sclerosis.^[7][8]

See also

• Cluster of differentiation

References

1. GRCh38: Ensembl release 89: ENSG00000013725 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024670 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: CD6 CD6 molecule".
6. Bowen MA, Patel DD, Li X, Modrell B, Malacko AR, Wang WC, Marquardt H, Neubauer M, Pesando JM, Francke U (1995). "Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand". J. Exp. Med. 181 (6): 2213–20. doi:10.1084/jem.181.6.2213. PMC 2192054. PMID 7760007.
7. De Jager PL, Jia X, Wang J, de Bakker PI, Ottoboni L, Aggarwal NT, Piccio L, Raychaudhuri S, Tran D, Aubin C, Briskin R, Romano S, Baranzini SE, McCauley JL, Pericak-Vance MA, Haines JL, Gibson RA, Naeglin Y, Uitdehaag B, Matthews PM, Kappos L, Polman C, McArdle WL, Strachan DP, Evans D, Cross AH, Daly MJ, Compston A, Sawcer SJ, Weiner HL, Hauser SL, Hafler DA, Oksenberg JR (2009). "Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci". Nat. Genet. 41 (7): 776–82. doi:10.1038/ng.401. PMC 2757648. PMID 19525953.
8. Kofler DM, Severson CA, Mousissian N, De Jager PL, Hafler DA (2011). "The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation". J. Immunol. 187 (6): 3286–91. doi:10.4049/jimmunol.1100626. PMID 21849685.

Further reading

• Aruffo A, Melnick MB, Linsley PS, Seed B (1991). "The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins". J. Exp. Med. 174 (4): 949–52. doi:10.1084/jem.174.4.949. PMC 2118957. PMID 1919444.
• Swack JA, Mier JW, Romain PL, Hull SR, Rudd CE (1991). "Biosynthesis and post-translational modification of CD6, a T cell signal-transducing molecule". J. Biol. Chem. 266 (11): 7137–43. doi:10.1016/S0021-9258(20)89621-5. PMID 2016320.
• Tsuge I, Utsumi KR, Ueda R, Takamoto S, Takahashi T (1985). "Assignment of gene coding human T-cell differentiation antigen, Tp120, to chromosome 11". Somat. Cell Mol. Genet. 11 (3): 217–22. doi:10.1007/BF01534678. PMID 3923629. S2CID 39343360.
• Whitney GS, Starling GC, Bowen MA, Modrell B, Siadak AW, Aruffo A (1995). "The membrane-proximal scavenger receptor cysteine-rich domain of CD6 contains the activated leukocyte cell adhesion molecule binding site". J. Biol. Chem. 270 (31): 18187–90. doi:10.1074/jbc.270.31.18187. PMID 7543097.
• Robinson WH, Neuman de Vegvar HE, Prohaska SS, Rhee JW, Parnes JR (1995). "Human CD6 possesses a large, alternatively spliced cytoplasmic domain". Eur. J. Immunol. 25 (10): 2765–9. doi:10.1002/eji.1830251008. PMID 7589069. S2CID 8996113.
• Wee S, Schieven GL, Kirihara JM, Tsu TT, Ledbetter JA, Aruffo A (1993). "Tyrosine phosphorylation of CD6 by stimulation of CD3: augmentation by the CD4 and CD2 coreceptors". J. Exp. Med. 177 (1): 219–23. doi:10.1084/jem.177.1.219. PMC 2190871. PMID 7678115.
• Bowen MA, Whitney GS, Neubauer M, Starling GC, Palmer D, Zhang J, Nowak NJ, Shows TB, Aruffo A (1997). "Structure and chromosomal location of the human CD6 gene: detection of five human CD6 isoforms". J. Immunol. 158 (3): 1149–56. doi:10.4049/jimmunol.158.3.1149. PMID 9013954. S2CID 24196035.
• Kobarg J, Whitney GS, Palmer D, Aruffo A, Bowen MA (1998). "Analysis of the tyrosine phosphorylation and calcium fluxing of human CD6 isoforms with different cytoplasmatic domains". Eur. J. Immunol. 27 (11): 2971–80. doi:10.1002/eji.1830271133. PMID 9394826. S2CID 20897222.
• Singer NG, Mitra R, Lialios F, Richardson BC, Marks RM, Pesando JM, Fox DA, Nickoloff BJ (1998). "CD6 dependent interactions of T cells and keratinocytes: functional evidence for a second CD6 ligand on gamma-interferon activated keratinocytes". Immunol. Lett. 58 (1): 9–14. doi:10.1016/S0165-2478(97)02707-7. PMID 9436462.
• Gimferrer I, Farnós M, Calvo M, Mittelbrunn M, Enrich C, Sánchez-Madrid F, Vives J, Lozano F (2003). "The accessory molecules CD5 and CD6 associate on the membrane of lymphoid T cells". J. Biol. Chem. 278 (10): 8564–71. doi:10.1074/jbc.M209591200. PMID 12473675.
• Shin BK, Wang H, Yim AM, Le Naour F, Brichory F, Jang JH, Zhao R, Puravs E, Tra J, Michael CW, Misek DE, Hanash SM (2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function". J. Biol. Chem. 278 (9): 7607–16. doi:10.1074/jbc.M210455200. PMID 12493773.
• Gimferrer I, Ibáñez A, Farnós M, Sarrias MR, Fenutría R, Roselló S, Zimmermann P, David G, Vives J, Serra-Pagès C, Lozano F (2005). "The lymphocyte receptor CD6 interacts with syntenin-1, a scaffolding protein containing PDZ domains". J. Immunol. 175 (3): 1406–14. doi:10.4049/jimmunol.175.3.1406. PMID 16034076.
• Kato Y, Tanaka Y, Hayashi M, Okawa K, Minato N (2006). "Involvement of CD166 in the activation of human gamma delta T cells by tumor cells sensitized with nonpeptide antigens". J. Immunol. 177 (2): 877–84. doi:10.4049/jimmunol.177.2.877. PMID 16818742.
• Ibáñez A, Sarrias MR, Farnós M, Gimferrer I, Serra-Pagès C, Vives J, Lozano F (2006). "Mitogen-activated protein kinase pathway activation by the CD6 lymphocyte surface receptor". J. Immunol. 177 (2): 1152–9. doi:10.4049/jimmunol.177.2.1152. PMID 16818773.
• Hassan NJ, Simmonds SJ, Clarkson NG, Hanrahan S, Puklavec MJ, Bomb M, Barclay AN, Brown MH (2006). "CD6 Regulates T-Cell Responses through Activation-Dependent Recruitment of the Positive Regulator SLP-76". Mol. Cell. Biol. 26 (17): 6727–38. doi:10.1128/MCB.00688-06. PMC 1592849. PMID 16914752.
• Castro MA, Oliveira MI, Nunes RJ, Fabre S, Barbosa R, Peixoto A, Brown MH, Parnes JR, Bismuth G, Moreira A, Rocha B, Carmo AM (2007). "Extracellular isoforms of CD6 generated by alternative splicing regulate targeting of CD6 to the immunological synapse". J. Immunol. 178 (7): 4351–61. doi:10.4049/jimmunol.178.7.4351. PMID 17371992.
• Sarrias MR, Farnós M, Mota R, Sánchez-Barbero F, Ibáñez A, Gimferrer I, Vera J, Fenutría R, Casals C, Yélamos J, Lozano F (2007). "CD6 binds to pathogen-associated molecular patterns and protects from LPS-induced septic shock". Proc. Natl. Acad. Sci. U.S.A. 104 (28): 11724–9. Bibcode:2007PNAS..10411724S. doi:10.1073/pnas.0702815104. PMC 1913855. PMID 17601777.

External links

• CD6+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human CD6 genome location and CD6 gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: P30203 (Human T-cell differentiation antigen CD6) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.