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Computational biology refers to the use of data analysis, mathematical modeling and computational simulations to understand biological systems and relationships.[1] An intersection of computer science, biology, and big data, the field also has foundations in applied mathematics, chemistry, and genetics.[2] It differs from biological computing, a subfield of computer engineering which uses bioengineering to build computers.

This timeline displays the year-by-year progress of the Human Genome Project in the context of genetics since 1865. Starting in 1990, by 1999, chromosome 22 became the first human chromosome to be completely sequenced.