E4F1

Transcription factor E4F1 is a protein that in humans is encoded by the E4F1 gene.^[5][6][7]

E4F1
Identifiers
Aliases	E4F1, E4F, E4F transcription factor 1
External IDs	OMIM: 603022; MGI: 109530; HomoloGene: 3259; GeneCards: E4F1; OMA:E4F1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 2,223,580 bp[1] End 2,235,742 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A3.3|17 12.39 cM Start 24,662,752 bp[2] End 24,689,287 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum sural nerve right lobe of thyroid gland granulocyte left lobe of thyroid gland pituitary gland skin of leg skin of abdomen apex of heart anterior pituitary Top expressed in granulocyte neural layer of retina muscle of thigh lip right kidney superior frontal gyrus urethra morula morula ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription corepressor activity DNA-binding transcription factor activity transcription coactivator activity metal ion binding protein binding DNA-binding transcription repressor activity, RNA polymerase II-specific nucleic acid binding cAMP response element binding transferase activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm spindle nucleoplasm nucleus Biological process regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated cell division DNA replication regulation of mitotic cell cycle, embryonic protein ubiquitination regulation of growth cell cycle cell population proliferation viral process regulation of cell cycle process positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1877 13560 Ensembl ENSG00000167967 ENSMUSG00000024137 UniProt Q66K89 Q8CCE9 RefSeq (mRNA) NM_001288776 NM_001288778 NM_004424 NM_001301784 NM_007893 NM_001355708 RefSeq (protein) NP_001275705 NP_001275707 NP_004415 NP_001288713 NP_031919 NP_001342637 Location (UCSC) Chr 16: 2.22 – 2.24 Mb Chr 17: 24.66 – 24.69 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence.^[7]

Interactions

E4F1 has been shown to interact with:

• P16,^[8]
• P53,^[8][9] and
• RB1^[10]

References

1. GRCh38: Ensembl release 89: ENSG00000167967 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024137 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Saccone S, Sandy P, Meroni G, Gostissa M, Della Valle G, Del Sal G (November 1998). "Assignment of the E1A-regulated transcription factor E4F gene (E4F1) to human chromosome band 16p13.3 by in situ hybridization and somatic cell hybrids". Cytogenet Cell Genet. 82 (1–2): 99–100. doi:10.1159/000015075. PMID 9763670. S2CID 46826484.
6. Burn TC, Connors TD, Van Raay TJ, Dackowski WR, Millholland JM, Klinger KW, Landes GM (December 1996). "Generation of a transcriptional map for a 700-kb region surrounding the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis type 2 (TSC2) disease genes on human chromosome 16p3.3". Genome Res. 6 (6): 525–537. doi:10.1101/gr.6.6.525. PMID 8828041.
7. "Entrez Gene: E4F1 E4F transcription factor 1".
8. Rizos H, Diefenbach E, Badhwar P, Woodruff S, Becker TM, Rooney RJ, Kefford RF (February 2003). "Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition". J. Biol. Chem. 278 (7): 4981–4989. doi:10.1074/jbc.M210978200. PMID 12446718.
9. Sandy P, Gostissa M, Fogal V, Cecco LD, Szalay K, Rooney RJ, Schneider C, Del Sal G (January 2000). "p53 is involved in the p120E4F-mediated growth arrest". Oncogene. 19 (2): 188–199. doi:10.1038/sj.onc.1203250. PMID 10644996.
10. Fajas L, Paul C, Zugasti O, Le Cam L, Polanowska J, Fabbrizio E, Medema R, Vignais ML, Sardet C (July 2000). "pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F". Proc. Natl. Acad. Sci. U.S.A. 97 (14): 7738–7743. Bibcode:2000PNAS...97.7738F. doi:10.1073/pnas.130198397. PMC 16614. PMID 10869426.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Fernandes ER, Rooney RJ (1997). "The adenovirus E1A-regulated transcription factor E4F is generated from the human homolog of nuclear factor phiAP3". Mol. Cell. Biol. 17 (4): 1890–1903. doi:10.1128/mcb.17.4.1890. PMC 232036. PMID 9121437.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Rooney RJ, Daniels RR, Jenkins NA, Gilbert DJ, Rothammer K, Morris SW, Higgs DR, Copeland NG (1998). "Chromosomal location and tissue expression of the gene encoding the adenovirus E1A-regulated transcription factor E4F in humans and mice". Mamm. Genome. 9 (4): 320–323. doi:10.1007/s003359900758. PMID 9530632. S2CID 31200297.
• Kim ST, Lim DS, Canman CE, Kastan MB (2000). "Substrate specificities and identification of putative substrates of ATM kinase family members". J. Biol. Chem. 274 (53): 37538–37543. doi:10.1074/jbc.274.53.37538. PMID 10608806.
• Sandy P, Gostissa M, Fogal V, Cecco LD, Szalay K, Rooney RJ, Schneider C, Del Sal G (2000). "p53 is involved in the p120E4F-mediated growth arrest". Oncogene. 19 (2): 188–199. doi:10.1038/sj.onc.1203250. PMID 10644996.
• Fajas L, Paul C, Zugasti O, Le Cam L, Polanowska J, Fabbrizio E, Medema R, Vignais ML, Sardet C (2000). "pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F". Proc. Natl. Acad. Sci. U.S.A. 97 (14): 7738–7743. Bibcode:2000PNAS...97.7738F. doi:10.1073/pnas.130198397. PMC 16614. PMID 10869426.
• Rizos H, Diefenbach E, Badhwar P, Woodruff S, Becker TM, Rooney RJ, Kefford RF (2003). "Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition". J. Biol. Chem. 278 (7): 4981–4989. doi:10.1074/jbc.M210978200. PMID 12446718.
• Fenton SL, Dallol A, Agathanggelou A, Hesson L, Ahmed-Choudhury J, Baksh S, Sardet C, Dammann R, Minna JD, Downward J, Maher ER, Latif F (2004). "Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene". Cancer Res. 64 (1): 102–107. doi:10.1158/0008-5472.CAN-03-2622. PMID 14729613. S2CID 13897912.
• Nakamura Y, Igarashi K, Suzuki T, Kanno J, Inoue T, Tazawa C, Saruta M, Ando T, Moriyama N, Furukawa T, Ono M, Moriya T, Ito K, Saito H, Ishibashi T, Takahashi S, Yamada S, Sasano H (2005). "E4F1, a novel estrogen-responsive gene in possible atheroprotection, revealed by microarray analysis". Am. J. Pathol. 165 (6): 2019–2031. doi:10.1016/s0002-9440(10)63253-1. PMC 1618705. PMID 15579445.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Paul C, Lacroix M, Iankova I, Julien E, Schäfer BW, Labalette C, Wei Y, Le Cam A, Le Cam L, Sardet C (2006). "The LIM-only protein FHL2 is a negative regulator of E4F1". Oncogene. 25 (40): 5475–5484. doi:10.1038/sj.onc.1209567. PMID 16652157. S2CID 19655591.
• Le Cam L, Linares LK, Paul C, Julien E, Lacroix M, Hatchi E, Triboulet R, Bossis G, Shmueli A, Rodriguez MS, Coux O, Sardet C (2006). "E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation". Cell. 127 (4): 775–788. doi:10.1016/j.cell.2006.09.031. PMID 17110336. S2CID 542082.
• Cvetanovic M, Rooney RJ, Garcia JJ, Toporovskaya N, Zoghbi HY, Opal P (2007). "The role of LANP and ataxin 1 in E4F-mediated transcriptional repression". EMBO Rep. 8 (7): 671–677. doi:10.1038/sj.embor.7400983. PMC 1905893. PMID 17557114.

External links

• E4F1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.