Entacapone
Chemical compound / From Wikipedia, the free encyclopedia
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Entacapone, sold under the brand name Comtan among others, is a medication commonly used in combination with other medications for the treatment of Parkinson's disease.[2] Entacapone together with levodopa and carbidopa allows levodopa to have a longer effect in the brain and reduces Parkinson's disease signs and symptoms for a greater length of time than levodopa and carbidopa therapy alone.[2]
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Pronunciation | /ˌɛntəkəˈpoʊn/ or /ɛnˈtækəpoʊn/ |
Trade names | Comtan (single ingredient), Stalevo (multi-ingredient) |
AHFS/Drugs.com | Monograph |
MedlinePlus | a601236 |
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Routes of administration | By mouth |
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Bioavailability | 35% |
Protein binding | 98% (binds to serum albumin) |
Metabolism | Hepatic |
Elimination half-life | 0.4–0.7 hours |
Excretion | Feces (90%), urine (10%) |
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ECHA InfoCard | 100.128.566 |
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Formula | C14H15N3O5 |
Molar mass | 305.290 g·mol−1 |
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Entacapone is a selective and reversible inhibitor of the enzyme catechol-O-methyltransferase (COMT).[2] When taken together with levodopa (L-DOPA) and carbidopa, entacapone stops catechol-O-methyltransferase from breaking down and metabolizing levodopa, resulting in an overall increase of levodopa remaining in the brain and body.[2]
Carbidopa/levodopa/entacapone (Stalevo), a medication developed by Orion Pharma and marketed by Novartis, is a single tablet formulation that contains levodopa, carbidopa, and entacapone.[3]