FGFBP1

Fibroblast growth factor-binding protein 1 is a protein that in humans is encoded by the FGFBP1 gene.^[5][6][7]

FGFBP1
Identifiers
Aliases	FGFBP1, FGF-BP, FGF-BP1, FGFBP, FGFBP-1, HBP17, fibroblast growth factor binding protein 1
External IDs	OMIM: 607737; MGI: 1096350; HomoloGene: 3766; GeneCards: FGFBP1; OMA:FGFBP1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p15.32 Start 15,935,577 bp[1] End 15,938,740 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 B3 Start 44,136,200 bp[2] End 44,139,121 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of pharynx gums gingival epithelium mucosa of esophagus oral cavity mucosa of transverse colon human penis vulva skin of abdomen skin of leg Top expressed in corneal stroma mucous cell of stomach skin of abdomen epithelium of stomach optic nerve esophagus belly cord lip pyloric antrum left colon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function fibroblast growth factor binding heparin binding protein binding growth factor binding Cellular component extracellular region cell surface plasma membrane membrane extracellular space Biological process positive regulation of fibroblast growth factor receptor signaling pathway fibroblast growth factor receptor signaling pathway signal transduction positive regulation of cell population proliferation negative regulation of cell population proliferation cell-cell signaling positive regulation of cell migration involved in sprouting angiogenesis positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9982 14181 Ensembl ENSG00000137440 ENSMUSG00000048373 UniProt Q14512 O70514 RefSeq (mRNA) NM_005130 NM_001271616 NM_008009 RefSeq (protein) NP_005121 NP_001258545 NP_032035 Location (UCSC) Chr 4: 15.94 – 15.94 Mb Chr 5: 44.14 – 44.14 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

FGFBP1, or HBP17, binds to both acidic FGF1 and basic FGF2 fibroblast growth factors in a reversible manner. It also binds to perlecan (HSPG2).[supplied by OMIM]^[7]

Interactions

FGFBP1 has been shown to interaction with Perlecan.^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000137440 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000048373 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mongiat M, Otto J, Oldershaw R, Ferrer F, Sato JD, Iozzo RV (Mar 2001). "Fibroblast growth factor-binding protein is a novel partner for perlecan protein core". J Biol Chem. 276 (13): 10263–71. doi:10.1074/jbc.M011493200. PMID 11148217.
6. Wu DQ, Kan MK, Sato GH, Okamoto T, Sato JD (Oct 1991). "Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors". J Biol Chem. 266 (25): 16778–85. doi:10.1016/S0021-9258(18)55368-0. PMID 1885605.
7. "Entrez Gene: FGFBP1 fibroblast growth factor binding protein 1".

Further reading

• Abuharbeid S, Czubayko F, Aigner A (2006). "The fibroblast growth factor-binding protein FGF-BP". Int. J. Biochem. Cell Biol. 38 (9): 1463–8. doi:10.1016/j.biocel.2005.10.017. PMID 16324873.
• Lange LG, Sytkowski AJ, Vallee BL (1976). "Human liver alcohol dehydrogenase: purification, composition, and catalytic features". Biochemistry. 15 (21): 4687–93. doi:10.1021/bi00666a023. PMID 9982.
• Czubayko F, Liaudet-Coopman ED, Aigner A, et al. (1997). "A secreted FGF-binding protein can serve as the angiogenic switch in human cancer". Nat. Med. 3 (10): 1137–40. doi:10.1038/nm1097-1137. PMID 9334727. S2CID 3633113.
• Wang XC, Chen JH, Crab JW, Sato JD (1998). "Purification of heparin-binding protein HBp17 and identification of HBp17 heparin binding site". Biochem. Mol. Biol. Int. 46 (1): 81–7. doi:10.1080/15216549800203582. PMID 9784842. S2CID 44789730.
• Harris VK, Coticchia CM, Kagan BL, et al. (2000). "Induction of the angiogenic modulator fibroblast growth factor-binding protein by epidermal growth factor is mediated through both MEK/ERK and p38 signal transduction pathways". J. Biol. Chem. 275 (15): 10802–11. doi:10.1074/jbc.275.15.10802. PMID 10753873.
• Sauter ER, Nesbit M, Tichansky D, et al. (2001). "Fibroblast growth factor-binding protein expression changes with disease progression in clinical and experimental human squamous epithelium". Int. J. Cancer. 92 (3): 374–81. doi:10.1002/ijc.1207. PMID 11291074. S2CID 20415335.
• Chen JH, Wang XC, Sato JD (2001). "Bifunctional effects of heparin-binding protein HBp17 on DNA synthesis in cells". Cell Biol. Int. 25 (6): 567–70. doi:10.1006/cbir.2000.0688. PMID 11407864. S2CID 19909718.
• Tassi E, Al-Attar A, Aigner A, et al. (2001). "Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein". J. Biol. Chem. 276 (43): 40247–53. doi:10.1074/jbc.M104933200. PMID 11509569.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Beer HD, Bittner M, Niklaus G, et al. (2005). "The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair". Oncogene. 24 (34): 5269–77. doi:10.1038/sj.onc.1208560. PMID 15806171. S2CID 75364.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Xie B, Tassi E, Swift MR, et al. (2006). "Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display". J. Biol. Chem. 281 (2): 1137–44. doi:10.1074/jbc.M510754200. PMID 16257968.
• Ray PE, Tassi E, Liu XH, Wellstein A (2006). "Role of fibroblast growth factor-binding protein in the pathogenesis of HIV-associated hemolytic uremic syndrome". Am. J. Physiol. Regul. Integr. Comp. Physiol. 290 (1): R105–13. doi:10.1152/ajpregu.00492.2005. PMID 16352855. S2CID 25248653.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.