Fludarabine
Chemical compound / From Wikipedia, the free encyclopedia
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Fludarabine is a purine analogue and antineoplastic agent. It is generally used as its 5-O-phosphorylated form known as fludarabine phosphate, sold under the brand name Fludara among others. It is a chemotherapy medication used in the treatment of leukemia and lymphoma.[3] These include chronic lymphocytic leukemia, non-Hodgkin's lymphoma, acute myeloid leukemia, and acute lymphocytic leukemia.[3] It is given by injection into a vein or by mouth.[3]
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Trade names | Fludara, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a692003 |
Routes of administration | Intravenous, by mouth |
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Bioavailability | 55% |
Protein binding | 19 to 29% |
Elimination half-life | 20 hours |
Excretion | Kidney |
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ECHA InfoCard | 100.123.703 |
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Formula | C10H12FN5O4 |
Molar mass | 285.235 g·mol−1 |
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Common side effects include nausea, diarrhea, fever, rash, shortness of breath, numbness, vision changes, and feeling tired.[3] Severe side effects include brain dysfunction, low blood cell counts, and lung inflammation.[3] Use in pregnancy will likely result in harm to the fetus.[3] Fludarabine is in the purine analog family of medications and works by interfering with the duplication of DNA.[3][4]
Fludarabine was approved for medical use in the United States in 1991.[3] It is on the World Health Organization's List of Essential Medicines.[5]