GPR21

Probable G-protein coupled receptor 21 is a protein that in humans is encoded by the GPR21 gene.^[5]

GPR21
Identifiers
Aliases	GPR21, G protein-coupled receptor 21
External IDs	OMIM: 601909; MGI: 2441890; HomoloGene: 74546; GeneCards: GPR21; OMA:GPR21 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q33.2 Start 123,033,667 bp[1] End 123,035,665 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 B Start 37,406,344 bp[2] End 37,410,615 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle right coronary artery popliteal artery tibial arteries left coronary artery ganglionic eminence Descending thoracic aorta prefrontal cortex ascending aorta muscle tissue Top expressed in ganglionic eminence mesencephalon neural tube embryo embryo morula rhombencephalon olfactory bulb tail of embryo secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function dopamine neurotransmitter receptor activity, coupled via Gs signal transducer activity G protein-coupled receptor activity Cellular component integral component of membrane plasma membrane membrane Biological process negative regulation of insulin receptor signaling pathway glucose homeostasis signal transduction positive regulation of multicellular organism growth G protein-coupled receptor signaling pathway dopamine receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2844 338346 Ensembl ENSG00000188394 ENSMUSG00000053164 UniProt Q99679 Q8BX79 RefSeq (mRNA) NM_005294 NM_177383 RefSeq (protein) NP_005285 NP_796357 Location (UCSC) Chr 9: 123.03 – 123.04 Mb Chr 2: 37.41 – 37.41 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000188394 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000053164 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: GPR21 G protein-coupled receptor 21".

Further reading

• O'Dowd BF, Nguyen T, Jung BP, et al. (1997). "Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes". Gene. 187 (1): 75–81. doi:10.1016/S0378-1119(96)00722-6. PMID 9073069.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.