Leukocyte receptor tyrosine kinase

Leukocyte receptor tyrosine kinase is an enzyme that in humans is encoded by the LTK gene.^[5][6]

LTK
Identifiers
Aliases	LTK, TYK1, Leukocyte receptor tyrosine kinase
External IDs	OMIM: 151520; MGI: 96840; HomoloGene: 130502; GeneCards: LTK; OMA:LTK - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q15.1 Start 41,503,637 bp[1] End 41,513,887 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 E5|2 59.97 cM Start 119,581,801 bp[2] End 119,590,912 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon right lung parotid gland testicle upper lobe of left lung duodenum rectum jejunal mucosa olfactory zone of nasal mucosa body of stomach Top expressed in perirhinal cortex entorhinal cortex CA3 field Ileal epithelium lactiferous gland embryo visual cortex primary visual cortex olfactory epithelium superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding kinase activity transmembrane receptor protein tyrosine kinase activity protein tyrosine kinase activity ATP binding protein binding receptor tyrosine kinase transmembrane signaling receptor activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane intracellular anatomical structure cytoplasm receptor complex Biological process cellular response to retinoic acid phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cardiac muscle cell apoptotic process negative regulation of apoptotic process protein phosphorylation positive regulation of neuron projection development phosphatidylinositol 3-kinase signaling cell population proliferation peptidyl-tyrosine phosphorylation signal transduction negative regulation of signal transduction cell differentiation positive regulation of ERK1 and ERK2 cascade regulation of neuron differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4058 17005 Ensembl ENSG00000062524 ENSMUSG00000027297 UniProt P29376 P08923 RefSeq (mRNA) NM_001135685 NM_002344 NM_206961 NM_008523 NM_203345 NM_206941 NM_206942 RefSeq (protein) NP_001129157 NP_002335 NP_996844 NP_032549 NP_976220 NP_996824 NP_996825 Location (UCSC) Chr 15: 41.5 – 41.51 Mb Chr 2: 119.58 – 119.59 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a member of the ALK/LTK receptor family of receptor tyrosine kinases (RTKs) whose ligand is unknown.^[7] Closely related to the insulin receptor family of RTKs. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.^[6]

Interactions

LTK has been shown to interact with IRS-1, Shc, and PIK3R1.^[8][9]

References

1. GRCh38: Ensembl release 89: ENSG00000062524 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027297 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Maru Y, Hirai H, Takaku F (May 1990). "Human ltk: gene structure and preferential expression in human leukemic cells". Oncogene Res. 5 (3): 199–204. PMID 2320375.
6. "Entrez Gene: LTK leukocyte tyrosine kinase".
7. Lopes SS, Yang X, Müller J, Carney TJ, McAdow AR, Rauch GJ, Jacoby AS, Hurst LD, Delfino-Machín M, Haffter P, Geisler R, Johnson SL, Ward A, Kelsh RN (2008). "Leukocyte tyrosine kinase functions in pigment cell development". PLOS Genet. 4 (3): e1000026. doi:10.1371/journal.pgen.1000026. PMC 2265441. PMID 18369445.
8. Kozutsumi H, Toyoshima H, Hagiwara K, Yazaki Y, Hirai H (October 1994). "Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo". Oncogene. 9 (10): 2991–8. PMID 8084603.
9. Ueno H, Honda H, Nakamoto T, Yamagata T, Sasaki K, Miyagawa K, Mitani K, Yazaki Y, Hirai H (June 1997). "The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase". Oncogene. 14 (25): 3067–72. doi:10.1038/sj.onc.1201153. PMID 9223670.

Further reading

• Krolewski JJ, Dalla-Favera R (1991). "The ltk gene encodes a novel receptor-type protein tyrosine kinase". EMBO J. 10 (10): 2911–9. doi:10.1002/j.1460-2075.1991.tb07841.x. PMC 453005. PMID 1655406.
• Krolewski JJ, Lee R, Eddy R, Shows TB, Dalla-Favera R (1990). "Identification and chromosomal mapping of new human tyrosine kinase genes". Oncogene. 5 (3): 277–82. PMID 2156206.
• Ben-Neriah Y, Bauskin AR (1988). "Leukocytes express a novel gene encoding a putative transmembrane protein-kinase devoid of an extracellular domain". Nature. 333 (6174): 672–6. Bibcode:1988Natur.333..672B. doi:10.1038/333672a0. PMID 2836739. S2CID 4262549.
• Toyoshima H, Kozutsumi H, Maru Y, Hagiwara K, Furuya A, Mioh H, Hanai N, Takaku F, Yazaki Y, Hirai H (1993). "Differently spliced cDNAs of human leukocyte tyrosine kinase receptor tyrosine kinase predict receptor proteins with and without a tyrosine kinase domain and a soluble receptor protein". Proc. Natl. Acad. Sci. U.S.A. 90 (12): 5404–8. Bibcode:1993PNAS...90.5404T. doi:10.1073/pnas.90.12.5404. PMC 46728. PMID 7685902.
• Richard I, Broux O, Chiannilkulchai N, Fougerousse F, Allamand V, Bourg N, Brenguier L, Devaud C, Pasturaud P, Roudaut C (1995). "Regional localization of human chromosome 15 loci". Genomics. 23 (3): 619–27. doi:10.1006/geno.1994.1550. PMID 7851890.
• Kozutsumi H, Toyoshima H, Hagiwara K, Yazaki Y, Hirai H (1994). "Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo". Oncogene. 9 (10): 2991–8. PMID 8084603.
• Kozutsumi H, Toyoshima H, Hagiwara K, Furuya A, Mioh H, Hanai N, Yazaki Y, Hirai H (1993). "Identification of the human ltk gene product in placenta and hematopoietic cell lines". Biochem. Biophys. Res. Commun. 190 (2): 674–9. doi:10.1006/bbrc.1993.1101. PMID 8427607.
• Ueno H, Sasaki K, Kozutsumi H, Miyagawa K, Mitani K, Yazaki Y, Hirai H (1996). "Growth and survival signals transmitted via two distinct NPXY motifs within leukocyte tyrosine kinase, an insulin receptor-related tyrosine kinase". J. Biol. Chem. 271 (44): 27707–14. doi:10.1074/jbc.271.44.27707. PMID 8910363.
• Snijders AJ, Ho SC, Haase VH, Pillai S, Bernards A (1997). "A lymphocyte-specific Ltk tyrosine kinase isoform is retained in the endoplasmic reticulum in association with calnexin". J. Biol. Chem. 272 (2): 1297–301. doi:10.1074/jbc.272.2.1297. PMID 8995435.
• Ueno H, Honda H, Nakamoto T, Yamagata T, Sasaki K, Miyagawa K, Mitani K, Yazaki Y, Hirai H (1997). "The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase". Oncogene. 14 (25): 3067–72. doi:10.1038/sj.onc.1201153. PMID 9223670.
• Espanel X, Huguenin-Reggiani M, Hooft van Huijsduijnen R (2003). "The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities". Protein Sci. 11 (10): 2326–34. doi:10.1110/ps.0213402. PMC 2373693. PMID 12237455.
• Li N, Nakamura K, Jiang Y, Tsurui H, Matsuoka S, Abe M, Ohtsuji M, Nishimura H, Kato K, Kawai T, Atsumi T, Koike T, Shirai T, Ueno H, Hirose S (2004). "Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus". Hum. Mol. Genet. 13 (2): 171–9. doi:10.1093/hmg/ddh020. PMID 14695357.