David Frankel (entrepreneur), is a South African-born American businessman. He is the co-founder of Founder Collective, a seed-stage venture capital fund with offices in New York City and Cambridge
Derek Keys (born 1931), finance minister of South Africa, 1992-1994, in the cabinets of F W de Klerk and Nelson Mandela
Desmond Lachman (born 1948), economist and former IMF Deputy Director
Donald Gordon, founder of life insurance company Liberty Life in 1958 with R100,000 when he was 27 years old; awarded a knighthood in 2005
Elizabeth Bradley, Non-Executive Chairman of Toyota SA Limited; former Executive Director of AngloGold
Gail Kelly (born Gail Currer), Australian and South African businessperson; first woman CEO of a major Australian bank or top 15 company (2002)
Gary Barber, Chairman and CEO of Metro-Goldwyn-Mayer Bachelor of Commerce; certificate in the Theory of Accountancy
Gene Sherman, philanthropist, academic and expert on art, fashion and architecture.
Graham Mackay, former Chairman and Ex-CEO of SABMiller plc, the world's second largest beer brewer
Ivan Glasenberg, CEO of Glencore, one of the world's largest commodity trading companies; on the boards of mining companies Xstrata plc and Minara Resources Ltd
Nathan Kirsh, South African-born Swazi business magnate, with a property empire spanning the UK, Swaziland and Australia; has Swazi citizenship; has residency status in the UK and the USA
Nthato Motlana, giant of South African business and the anti-apartheid struggle; one of the accused, with Mandela and 18 others, in the 1952 Defiance Campaign Trial
Patrice Motsepe, South African mining magnate; according to Forbes magazine, worth more than R17-billion after adding a further R7-billion to his net worth in 2009
Ronnie Apteker, founder of Internet Solutions, one of South Africa's largest internet service providers
Sir Ernest Oppenheimer, diamond and gold mining entrepreneur; financier; philanthropist; controlled De Beers; founded the Anglo American Corporation of South Africa
Sir Mark Weinberg, South African-born British financier; founder of Abbey Life Assurance Company
Sir Winfried Franz Wilhem Bischoff, Anglo-German banker; chairman of Lloyds Banking Group plc; former chairman and former interim CEO of Citigroup; knighted in 2000
Sol Kerzner, hotel and gambling magnate; created the most successful hotel group in South Africa, Sun International; Chairman of the Board of Kerzner International, based in the Bahamas
Steven H. Collis, CEO of Cencora (previously AmerisourceBergen);
Tony Trahar, former chairman of Anglo American; educated at St John's College and the University of the Witwatersrand
Prof Adam Habib, Vice-chancellor and Principal University of the Witwatersrand
Prof Brenda Gourley, higher education pioneer; accountant
Peter Sarnak, awarded the Wolf Prize 2014, Honorary doctorate 2014: University of the Witwatersrand
Prof Tshilidzi Marwala, Vice-chancellor and Principal University of Johannesburg
John Burland,[1] is an Emeritus Professor and Senior Research Investigator at the Department of Civil and Environmental Engineering of Imperial College London.[2]
Lewis Wolpert,[1] was a South African-born British developmental biologist, author, and broadcaster
Michael Bear (lord mayor),[1] is a civil engineer and management leader in both the construction and property industries in the UK and abroad
Rob Pullen,[1] major contributor to the practice of water resources engineering and especially to the wider engineering profession in South Africa
Matthew Rabinowitz, is a doctor of engineering and co-founder and executive chairman of Natera, a clinical genetic testing company
Sir Jack Zunz,[1] was a British civil engineer and former chairman of Ove Arup & Partners. He was the principal structural designer of the Sydney Opera House
Trevor Wadley, was a South African electrical engineer, best known for his development of the Wadley Loop circuit for greater stability in communications receivers and the Tellurometer, a land surveying device.
Jules Fejer was an engineer with South Africa's National Institute for Telecommunications Research (NITR), He published the first estimate of the life expectancy of the recently launched Sputnik in Nature.
Charles Hilliard Feinstein (18 March 1932 – 27 November 2004) was a noted South African and British economic historian. He was born in Johannesburg, received his early education at Parktown Boys' High School and studied at Witwatersrand University and Cambridge University where he completed his doctorate.
Azhar Cachalia (1956– ), Judge at the South African Supreme Court of Appeal; anti-apartheid activist; a founding member of the United Democratic Front; served as Secretary for Safety and Security
Beric John Croome (1960–2019), Advocate of the High Court of South Africa; CA (SA); taxpayers' rights legal pioneer; completed a Higher Diploma in Tax Law (cum laude) at Wits in 1989; awarded the Edward Nathan Friedland Tax Prize for the year; 2002 nominee for the University's Convocation Honour Award for his contribution to commerce and industry
John Dugard (1936– ), professor of international law and writer[2]
Richard Goldstone (1938– ), judge and international war crimes prosecutor; considered one of several liberal judges who issued key rulings that systematically undermined Apartheid
Nicholas Haysom (1952– ), diplomat and UN official; Chief Legal Adviser to President Nelson Mandela; until May 1994, an associate professor of law and deputy director at the Centre for Applied Legal Studies (CALS) at Wits
Bob Hepple (1934–2015), legal academic and leader in the fields of labour law, equality and human rights
Alan Menter (MBBCh, 1966, Wits), dermatologist; expert on psoriasis; Chairman of the Division of Dermatology; Director of the Dermatology Residency program for Baylor University Medical Center; Clinical Professor of Dermatology at the University of Texas Southwestern Medical School
Jonathan Lewis, surgical oncologist; biomedical researcher; developer of cancer drugs[3]
Joseph Sonnabend, physician, scientist and HIV/AIDS researcher, notable for pioneering community-based research, the propagation of safe sex to prevent infection, and an early multifactorial model of AIDS.
Julien Hoffman, paediatric cardiologist; cardiac physiologist; expert in the epidemiology of congenital cardiovascular malformations
Lionel Hersov, child psychiatrist, researcher and academic
Mary Malahlela, first black woman doctor in South Africa
Nandipha Magudumana, medical practitioner and celebrity doctor incarcerated and investigated for aiding a fugitive's prison escape
Norman E. Rosenthal, author, psychiatrist and scientist who in the 1980s first described seasonal affective disorder (SAD), and pioneered the use of light therapy for its treatment
Phillip Tobias, palaeoanthropologist and Professor Emeritus at the University of the Witwatersrand in Johannesburg; known for his work at South Africa's hominid fossil sites; anti-apartheid activist
Priscilla Kincaid-Smith, "the mother of nephrology", appointed Commander of The Order of the British Empire (Civil) in 1975, for services to medicine; appointed a Companion of the Order of Australia; first woman to become President of the Royal Australasian College of Physicians (1986–1988); won Australian Achiever Award in 1997 for a lifetime's work in renal health
Raymond Dart, Dean of the Faculty of Medicine, 1925-1943, the longest term of service in that capacity; announced the discovery of the Taung skull, the first of Africa's early hominids, and named the species Australopithecus Africanus
Rhian Touyz, MBBCh, MSc (Med), PhD, FRCP, FRSE,[1] FMedSci, FCAHS[2] is a Canadian medical researcher
Salome Maswime, obstetrician-gynecologist, global health expert and activist
John Edmund Kerrich, first head of the Statistics department. Famous for experiments in probability performed while interned (in Denmark) during the second world war.
David Lewis-Williams, Professor emeritus of Cognitive Archaeology at the University of the Witwatersrand; specialist in Upper-Palaeolithic and Bushmen rock art; founder of the Rock Art Research Institute at the University of the Witwatersrand
John Burland, Emeritus Professor and Senior Research Investigator at the Department of Civil and Environmental Engineering of Imperial College London; Professor of Geotechnical Engineering at the Imperial College, London; led the international consulting team that stabilized the leaning tower of Pisa; one of the few engineers to be elected a Fellow of the Royal Society
Lee Berger, paleoanthropologist, winner of the first National Geographic Prize for Research and Exploration
Lewis Wolpert, graduated in Civil Engineering; studied biology at Imperial College; Professor of Biology Applied to Medicine at University College, London; Fellow of the Royal Society; popular science lecturer and writer
Sir Basil Schonland, Honorary Doctor of Science (1957); founding director of the Bernard Price Institute of Geophysics at the University of the Witwatersrand; made significant contributions to the study of atmospheric electricity, photographing lightning and investigating the electric fields generated by thunderclouds
Tingye Li; pioneer in lasers and optical communication
Hendrik Ramaala, winner of the 2004 New York City Marathon and 2004 Mumbai Marathon; has two silver medals from the IAAF World Half Marathon Championships in 1998 and 1999; in 2006 he won the men's Great North Run; two-time national champion in the 5.000 metres