Nucleoporin 155

Nucleoporin 155 (Nup155) is a protein that in humans is encoded by the NUP155 gene.^[5][6]

NUP155
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5A9Q, 5IJN, 5IJO
Identifiers
Aliases	NUP155, ATFB15, N155, nucleoporin 155kDa, nucleoporin 155
External IDs	OMIM: 606694; MGI: 2181182; HomoloGene: 43155; GeneCards: NUP155; OMA:NUP155 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5p13.2 Start 37,288,137 bp[1] End 37,371,106 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 A1 Start 8,138,757 bp[2] End 8,190,731 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm left testis right testis secondary oocyte gonad testicle ventricular zone Achilles tendon embryo ganglionic eminence Top expressed in tail of embryo epiblast spermatocyte genital tubercle internal carotid artery external carotid artery maxillary prominence mandibular prominence pineal gland cumulus cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transporter activity protein binding structural constituent of nuclear pore Cellular component nuclear membrane membrane nuclear envelope nuclear pore nucleus nuclear pore inner ring host cell Biological process mRNA transport nuclear envelope organization viral transcription protein sumoylation mitotic nuclear membrane disassembly nucleocytoplasmic transport atrial cardiac muscle cell action potential regulation of cellular response to heat protein transport viral process intracellular transport of virus protein import into nucleus RNA export from nucleus tRNA export from nucleus transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery protein localization to nuclear inner membrane mRNA export from nucleus regulation of gene silencing by miRNA regulation of glycolytic process transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9631 170762 Ensembl ENSG00000113569 ENSMUSG00000022142 UniProt O75694 Q99P88 RefSeq (mRNA) NM_001278312 NM_004298 NM_153485 NM_133227 RefSeq (protein) NP_001265241 NP_004289 NP_705618 NP_573490 Location (UCSC) Chr 5: 37.29 – 37.37 Mb Chr 15: 8.14 – 8.19 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Nucleoporins are the main components of the nuclear pore complex (NPC) of eukaryotic cells. They are involved in the bidirectional trafficking of molecules, especially mRNAs and proteins, between the nucleus and the cytoplasm. The protein encoded by this gene does not contain the typical FG repeat sequences found in most vertebrate nucleoporins. Two protein isoforms are encoded by transcript variants of this gene.^[6]

Interactions

NUP155 has been shown to interact with GLE1L.^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000113569 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022142 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhang X, Yang H, Corydon MJ, Zhang X, Pedersen S, Korenberg JR, Chen XN, Laporte J, Gregersen N, Niebuhr E, Liu G, Bolund L (Jun 1999). "Localization of a human nucleoporin 155 gene (NUP155) to the 5p13 region and cloning of its cDNA". Genomics. 57 (1): 144–51. doi:10.1006/geno.1999.5741. PMID 10191094.
6. "Entrez Gene: NUP155 nucleoporin 155kDa".
7. Rayala, Heidi J; Kendirgi Frederic; Barry Dianne M; Majerus Philip W; Wente Susan R (Feb 2004). "The mRNA export factor human Gle1 interacts with the nuclear pore complex protein Nup155". Mol. Cell. Proteomics. 3 (2). United States: 145–55. doi:10.1074/mcp.M300106-MCP200. ISSN 1535-9476. PMID 14645504.

Further reading

• Görlich D, Mattaj IW (1996). "Nucleocytoplasmic transport". Science. 271 (5255): 1513–8. Bibcode:1996Sci...271.1513G. doi:10.1126/science.271.5255.1513. hdl:11858/00-001M-0000-002D-1CAE-4. PMID 8599106.
• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
• Zhang X, Yang H, Yu J, et al. (2002). "Genomic organization, transcript variants and comparative analysis of the human nucleoporin 155 (NUP155) gene". Gene. 288 (1–2): 9–18. doi:10.1016/S0378-1119(02)00470-5. PMID 12034489.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Rayala HJ, Kendirgi F, Barry DM, et al. (2004). "The mRNA export factor human Gle1 interacts with the nuclear pore complex protein Nup155". Mol. Cell. Proteomics. 3 (2): 145–55. doi:10.1074/mcp.M300106-MCP200. PMID 14645504.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hawryluk-Gara LA, Shibuya EK, Wozniak RW (2005). "Vertebrate Nup53 Interacts with the Nuclear Lamina and Is Required for the Assembly of a Nup93-containing Complex". Mol. Biol. Cell. 16 (5): 2382–94. doi:10.1091/mbc.E04-10-0857. PMC 1087243. PMID 15703211.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.