Nucleoporin 188

Nucleoporin 188 (Nup188) is a protein that in humans is encoded by the NUP188 gene.^[5][6]

NUP188
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5IJO
Identifiers
Aliases	NUP188, KIAA0169, hNup188, nucleoporin 188kDa, nucleoporin 188, SANDSTEF
External IDs	OMIM: 615587; MGI: 2446190; HomoloGene: 45683; GeneCards: NUP188; OMA:NUP188 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.11 Start 128,947,699 bp[1] End 129,007,096 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 B Start 30,176,409 bp[2] End 30,234,278 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis cerebellar hemisphere right hemisphere of cerebellum anterior pituitary testicle stromal cell of endometrium skin of leg gastric mucosa ectocervix Top expressed in spermatocyte spermatid seminiferous tubule epiblast tail of embryo ventricular zone Gonadal ridge zygote maxillary prominence mandibular prominence More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of nuclear pore Cellular component nuclear pore nucleus nuclear pore inner ring nuclear envelope membrane host cell Biological process mitotic nuclear membrane disassembly viral transcription protein import into nucleus viral process RNA export from nucleus protein sumoylation protein transport mRNA transport regulation of cellular response to heat intracellular transport of virus glomerular visceral epithelial cell migration mRNA export from nucleus tRNA export from nucleus regulation of gene silencing by miRNA regulation of glycolytic process transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23511 227699 Ensembl ENSG00000095319 ENSMUSG00000052533 UniProt Q5SRE5 Q6ZQH8 RefSeq (mRNA) NM_015354 NM_198304 RefSeq (protein) NP_056169 NP_938046 Location (UCSC) Chr 9: 128.95 – 129.01 Mb Chr 2: 30.18 – 30.23 Mb PubMed search [3] [4]
Wikidata
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Function

Transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP188 is part of one such subcomplex.^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000095319 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000052533 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: NUP188 nucleoporin 188kDa".
6. Miller BR, Powers M, Park M, Fischer W, Forbes DJ (October 2000). "Identification of a New Vertebrate Nucleoporin, Nup188, with the Use of a Novel Organelle Trap Assay". Mol. Biol. Cell. 11 (10): 3381–96. doi:10.1091/mbc.11.10.3381. PMC 15000. PMID 11029043.

External links

• Overview of all the structural information available in the PDB for UniProt: Q5SRE5 (Human Nucleoporin NUP188 homolog (NUP188)) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.