Pyrimidinylpiperazine
Chemical compound / From Wikipedia, the free encyclopedia
1-(2-Pyrimidinyl)piperazine (1-PP, 1-PmP) is a chemical compound and piperazine derivative. It is known to act as an antagonist of the α2-adrenergic receptor (Ki = 7.3–40 nM)[1] and, to a much lesser extent, as a partial agonist of the 5-HT1A receptor (Ki = 414 nM; Emax = 54%).[2][3] It has negligible affinity for the dopamine D2, D3, and D4 receptors (Ki > 10,000 nM) and does not appear to have significant affinity for the α1-adrenergic receptors.[4][additional citation(s) needed] Its crystal structure has been determined.[5]
"1-PP" redirects here. Not to be confused with 1PP.
Quick Facts Names, Identifiers ...
Names | |
---|---|
Preferred IUPAC name
2-(Piperazin-1-yl)pyrimidine | |
Identifiers | |
3D model (JSmol) |
|
ChEBI | |
ChEMBL | |
ChemSpider |
|
ECHA InfoCard | 100.040.107 |
EC Number |
|
PubChem CID |
|
UNII | |
CompTox Dashboard (EPA) |
|
| |
| |
Properties | |
C8H12N4 | |
Molar mass | 164.21 g/mol |
Hazards | |
GHS labelling: | |
Danger | |
H314, H315, H319, H335 | |
P260, P261, P264, P271, P280, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P332+P313, P337+P313, P362, P363, P403+P233, P405, P501 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|
Close