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Serotonin transporter

Mammalian protein found in Homo sapiens / From Wikipedia, the free encyclopedia

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The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene.[5] SERT is a type of monoamine transporter protein that transports the neurotransmitter serotonin from the synaptic cleft back to the presynaptic neuron, in a process known as serotonin reuptake.[6]

Quick facts: SLC6A4, Available structures, PDB, List of PD...
Available structures
PDBOrtholog search: PDBe RCSB
AliasesSLC6A4, 5-HTT, 5HTT, HTT, OCD1, SERT, SERT1, hSERT, Solute Carrier Family 6 (neurotransmitter transporter), member 4, solute carrier family 6 member 4, 5-HTTLPR
External IDsOMIM: 182138 MGI: 96285 HomoloGene: 817 GeneCards: SLC6A4
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 17: 30.19 – 30.24 MbChr 11: 76.89 – 76.92 Mb
PubMed search[3][4]
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This transport of serotonin by the SERT protein terminates the action of serotonin and recycles it in a sodium-dependent manner. Many antidepressant medications of the SSRI and tricyclic antidepressant classes work by binding to SERT and thus reducing serotonin reuptake.[7] It is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, post-traumatic stress disorder and depression-susceptibility in people experiencing emotional trauma.[8]