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Chemical compound From Wikipedia, the free encyclopedia
Sodium calcium edetate (sodium calcium EDTA), also known as edetate calcium disodium among other names, is a medication primarily used to treat lead poisoning,[2] including both short-term and long-term lead poisoning.[3] Sodium calcium edetate came into medical use in the United States in 1953.[3]
Clinical data | |
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Trade names | Calcium disodium versenate, others |
Other names | calcium disodium EDTA, edetate calcium disodium, sodium calcium edetate |
AHFS/Drugs.com | Monograph |
Routes of administration | IV, IM |
Drug class | chelating agent |
ATC code | |
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Identifiers | |
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CAS Number | |
PubChem CID | |
DrugBank | |
ChemSpider | |
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ChEBI | |
E number | E385 (antioxidants, ...) |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.000.482 |
Chemical and physical data | |
Formula | C10H12CaN2Na2O8 |
Molar mass | 374.270 g·mol−1 |
3D model (JSmol) | |
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Sodium calcium edetate is in the chelating agent family of medication.[3] It is a salt of edetate with two sodium and one calcium atoms.[4] It works by binding to a number of heavy metals, which renders them almost inert and allows them to leave the body in the urine.[3]
Edetate disodium (Endrate) is a different formulation which does not have the same effects.[3]
Sodium calcium edetate's primary use is to treat lead poisoning,[2] for which it is an alternative to succimer.[3] It is given by slow injection into a vein or into a muscle.[2]
For lead encephalopathy sodium calcium edetate is typically used together with dimercaprol.[3] It may also be used to treat plutonium poisoning.[5] It does not appear to be useful for poisoning by tetra-ethyl lead.[3]
Common side effects include pain at the site of injection.[3] Other side effects may include kidney problems, diarrhea, fever, muscle pains, and low blood pressure.[2] Benefits when needed in pregnancy are likely greater than the risks.[3]
Sodium calcium edetate came into medical use in the United States in 1953.[3] It is on the World Health Organization's List of Essential Medicines.[6]
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