Vigabatrin
Epilepsy medication / From Wikipedia, the free encyclopedia
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Vigabatrin, sold under the brand names Sabril and Vigpoder, is a medication used to treat epilepsy. It became available as a generic medication in 2019.[2]
Quick Facts Clinical data, Pronunciation ...
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Pronunciation | /vaɪˈɡæbətrɪn/ vy-GAB-ə-trin |
Trade names | Sabril, Vigpoder, Vigadrone |
Other names | γ-Vinyl-GABA |
AHFS/Drugs.com | Monograph |
MedlinePlus | a610016 |
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Routes of administration | By mouth |
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Pharmacokinetic data | |
Bioavailability | 80–90% |
Protein binding | 0% |
Metabolism | not metabolized |
Elimination half-life | 5–8 hours in young adults, 12–13 hours in the elderly. |
Excretion | Kidney |
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ECHA InfoCard | 100.165.122 |
Chemical and physical data | |
Formula | C6H11NO2 |
Molar mass | 129.159 g·mol−1 |
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Melting point | 171 to 177 °C (340 to 351 °F) |
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It works by inhibiting the breakdown of γ-aminobutyric acid (GABA). It is also known as γ-vinyl-GABA, and is a structural analogue of GABA, but does not bind to GABA receptors.[3]
Vigabatrin is generally used only in cases of treatment-resistant epilepsy due to the risk of permanent vision loss.[4]