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1-Naphthylmethcathinone

Pharmaceutical compound From Wikipedia, the free encyclopedia

1-Naphthylmethcathinone
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1-Naphthylmethcathinone (AMAPN) is a monoamine releasing agent of the cathinone and naphthylaminopropane families.[1][2] It is an analogue of methcathinone in which the phenyl ring has been replaced with a 1-naphthalene ring.[1][2]

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The drug acts as a potent serotonin–norepinephrine–dopamine releasing agent (SNDRA).[1][2] Its EC50Tooltip half-maximal effective concentration values for induction of monoamine release are 21.6 nM for serotonin and 55.2 nM for dopamine, whereas the EC50 for norepinephrine was not reported.[1] However, AMAPN induced 92% release of norepinephrine at a concentration of 10,000 nM, indicating that it is an effective norepinephrine releaser as well.[1]

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