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2C-T-27

Pharmaceutical compound From Wikipedia, the free encyclopedia

2C-T-27
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2C-T-27, also known as 4-benzylthio-2,5-dimethoxyphenethylamine, is a serotonin 5-HT2A receptor agonist and serotonergic psychedelic of the phenethylamine and 2C families.[1][2][3][4] It was first synthesized and described by Daniel Trachsel in 2003.[2][3]

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In addition to the serotonin 5-HT2A receptor, 2C-T-27 interacts with the serotonin 5-HT2C receptor.[4] It showed higher affinity for the serotonin 5-HT2A receptor than any other 2C drug (Ki = 1.6 nM), but its activational potency and efficacy were among the lowest (EC50Tooltip half-maximal effective concentration = 26 nM; EmaxTooltip maximal efficacy = 27%).[5][4]

The drug produces the head-twitch response (HTR), a behavioral proxy of psychedelic effects, in rodents.[5] However, the HTR induced by 2C-T-27 is relatively weak.[1]

2C-T-27 has been reported to produce hallucinogenic effects in humans.[1] Its dosage was reported by Trachsel to be 80 mg or more orally and no duration was listed.[1]

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