Daniel Trachsel

Daniel Trachsel is a Swiss chemist who studies psychedelics and entactogens.^[1][2] He has developed and published on a large number of novel psychedelic and entactogen compounds, including their psychoactive effects.^[1][2][3] This has been in a manner similar to that of the psychedelic chemist Alexander Shulgin, which has caused Trachsel to sometimes be referred to as the "German Shulgin".^[1][2] However, unlike Shulgin, Trachsel has distanced himself from any personal self-experiments.^[1]

Daniel Trachsel
Alma mater	Burgdorf University of Applied Sciences
Years active	1993–present
Organization	ReseaChem
Notable work	Psychedelische Chemie Aspekte psychoaktiver Moleküle (2000); Phenethylamine: von der Struktur zur Funktion (2013)
Website	https://nachtschatten.ch/autoren/trachsel/

According to Hamilton Morris and Nick Cozzi in mid-2023, Trachel's book Phenethylamine: von der Struktur zur Funktion (Phenethylamines: From Structure to Function) is in the process of being translated into English.^[4] It is being independently translated by the Alexander Shulgin Research Institute (ASRI), with tentative publication by Transform Press, and also by chemist David Carlson.^[4]

Compounds

Compounds that were first known to have been synthesized by Trachsel and colleagues include:

• 2C-BI-8
• 2C-CP
• 2C-Ph (2C-BI-1)
• 2C-T-3
• 2C-T-16
• 2C-T-21.5
• 2C-T-25
• 2C-T-27
• 2C-T-28
• 2C-T-30
• 2C-T-31
• 2C-T-32
• 2C-T-33
• 2C-TFE
• 2C-V
• 2C-YN
• 3C-DFE
• DFMDA
• Trifluoromescaline

Selected publications

Books

• Trachsel, D.; Richard, N. (2000). Psychedelische Chemie Aspekte psychoaktiver Moleküle [Psychedelic Chemistry: Aspects of Psychoactive Molecules] (in German) (1 ed.). Nachtschatten-Verlag. ISBN 978-3-907080-53-5. OCLC 247657972. Retrieved 31 January 2025. [Note: There are also several subsequent editions (2nd (2002) through 5th (2016)).]^[5]
• Trachsel, D.; Lehmann, D.; Enzensperger, C. (2013). Phenethylamine: von der Struktur zur Funktion [Phenethylamines: From Structure to Function]. Nachtschatten-Science (in German) (1 ed.). Solothurn: Nachtschatten-Verlag. ISBN 978-3-03788-700-4. OCLC 858805226. Retrieved 31 January 2025.

Papers

• Trachsel, Daniel (2002). "Synthese von neuen (Phenylalkyl)aminen zur Untersuchung von Struktur-Aktivitätsbeziehungen, Mitteilung 1, Mescalin Derivate" [Synthesis of new (phenylalkyl)amines for the investigation of structure-activity relationships, Communication 1, Mescaline derivatives] (PDF). Helvetica Chimica Acta. 85 (9): 3019–3026. doi:10.1002/1522-2675(200209)85:9<3019::AID-HLCA3019>3.0.CO;2-4.
• Trachsel, Daniel (2003). "Synthese von neuen (Phenylalkyl)aminen zur Untersuchung von Struktur–Aktivitätsbeziehungen. Mitteilung 2: 4-Thio-substituierte [2-(2,5-Dimethoxyphenyl)ethyl]amine (=2,5-Dimethoxybenzolethanamine)" [Synthesis of new (phenylalkyl)amines for the investigation of structure–activity relationships. Communication 2: 4-thio-substituted [2-(2,5-dimethoxyphenyl)ethyl]amines (=2,5-dimethoxybenzenethanamines)]. Helvetica Chimica Acta. 86 (7): 2610–2619. doi:10.1002/hlca.200390210. ISSN 0018-019X.
• Trachsel, Daniel (2003). "Synthesis of Novel (Phenylalkyl)amines for the Investigation of Structure–Activity Relationships, Part 3: 4-Ethynyl-2,5-dimethoxyphenethylamine (=4-Ethynyl-2,5-dimethoxybenzeneethanamine; 2C-YN)". Helvetica Chimica Acta. 86 (8): 2754–2759. doi:10.1002/hlca.200390224. ISSN 0018-019X.
• Trachsel D, Hadorn M, Baumberger F (March 2006). "Synthesis of fluoro analogues of 3,4-(methylenedioxy)amphetamine (MDA) and its derivatives". Chem Biodivers. 3 (3): 326–336. doi:10.1002/cbdv.200690035. PMID 17193269.
• Trachsel D, Nichols DE, Kidd S, Hadorn M, Baumberger F (May 2009). "4-aryl-substituted 2,5-dimethoxyphenethylamines: synthesis and serotonin 5-HT(2A) receptor affinities". Chem Biodivers. 6 (5): 692–704. doi:10.1002/cbdv.200800235. PMID 19479848.
• Trachsel D (2012). "Fluorine in psychedelic phenethylamines". Drug Test Anal. 4 (7–8): 577–590. doi:10.1002/dta.413. PMID 22374819.
• Luethi D, Trachsel D, Hoener MC, Liechti ME (May 2018). "Monoamine receptor interaction profiles of 4-thio-substituted phenethylamines (2C-T drugs)" (PDF). Neuropharmacology. 134 (Pt A): 141–148. doi:10.1016/j.neuropharm.2017.07.012. PMID 28720478.
• Kolaczynska KE, Luethi D, Trachsel D, Hoener MC, Liechti ME (2021). "Receptor Interaction Profiles of 4-Alkoxy-3,5-Dimethoxy-Phenethylamines (Mescaline Derivatives) and Related Amphetamines" (PDF). Front Pharmacol. 12: 794254. doi:10.3389/fphar.2021.794254. PMC 8865417. PMID 35222010.
• Halberstadt AL, Luethi D, Hoener MC, Trachsel D, Brandt SD, Liechti ME (January 2023). "Use of the head-twitch response to investigate the structure-activity relationships of 4-thio-substituted 2,5-dimethoxyphenylalkylamines" (PDF). Psychopharmacology (Berl). 240 (1): 115–126. doi:10.1007/s00213-022-06279-2. PMC 9816194. PMID 36477925.

See also

• David E. Nichols
• Jason Wallach