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CYB210010
Chemical compound From Wikipedia, the free encyclopedia
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CYB210010, also known as 2C-T-TFM or 2C-T-36 and as 2,5-dimethoxy-4-(trifluoromethylsulfanyl)phenethylamine, is a lesser-known psychedelic drug of the phenethylamine family related to compounds such as 2C-T and 2C-T-21.[2][3]
Alexander Shulgin attempted to synthesise this compound in the 1990s, and mentions it in his book PiHKAL under the entry for 2C-T-21, but was unsuccessful in producing a key intermediate and never assigned it a 2C-T number. This compound was ultimately first synthesised by Geoffrey Varty and colleagues at Irish biopharmaceutical company Cybin in 2023.[3]
It has a Ki of 0.35 nM at the serotonin 5-HT2A receptor, and an EC50 of 4.1 nM at the serotonin 5-HT2A receptor and 7.3 nM at the serotonin 5-HT2C receptor, compared to 88 nM at the serotonin 5-HT2B receptor.[4] It is a potent, selective, long acting, and orally active agonist for the serotonin 5-HT2A and 5-HT2C receptors and produces psychedelic-like responding in several different animal species.[2][3] The interactions of CYB210010 with numerous other receptors and targets have also been described.[2] It has only been studied preclinically as of 2024 and is not known to have been tested in humans.[2][3]
Related drugs include the deuterated phenethylamine CYB005 and the deuterated substituted tryptamines CYB003 and CYB004.[5][6]
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