3C-DFE

3C-DFE is a lesser-known psychedelic drug, which is a fluorinated derivative of 3C-E. It was first synthesised by Daniel Trachsel in 2002,^[1][2] and has been reported as showing similar psychedelic activity to related compounds, with a dose range of around 20–40 mg and a duration of approximately 10 hours.^[3]: 736 Despite its reported psychedelic activity, binding studies in vitro showed 3C-DFE to have a surprisingly weak binding affinity of 2695 nM at 5-HT_2A with negligible affinity at 5-HT_2C,^[3]: 737 making it only slightly higher affinity than mescaline, despite its higher potency in vivo.

3C-DFE

Names
Preferred IUPAC name 1-[4-(2,2-Difluoroethoxy)-3,5-dimethoxyphenyl]propan-2-amine
Other names 3C-DFE
Identifiers
CAS Number	501700-07-8 Y
3D model (JSmol)	Interactive image
ChemSpider	33260397 Y
PubChem CID	54939285
CompTox Dashboard (EPA)	DTXSID701032726
InChI InChI=1S/C13H19F2NO3/c1-8(16)4-9-5-10(17-2)13(11(6-9)18-3)19-7-12(14)15/h5-6,8,12H,4,7,16H2,1-3H3 Key: TYXHBMNQOVLYRX-UHFFFAOYSA-N InChI=1/C13H19F2NO3/c1-8(16)4-9-5-10(17-2)13(11(6-9)18-3)19-7-12(14)15/h5-6,8,12H,4,7,16H2,1-3H3 Key: TYXHBMNQOVLYRX-UHFFFAOYAC
SMILES COc1cc(CC(N)C)cc(OC)c1OCC(F)F
Properties
Chemical formula	C13H19FNO3
Molar mass	275.292 g/mol
Melting point	171–172 °C (340–342 °F; 444–445 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

See also

• 3C (psychedelics)
• 2C-TFE
• Escaline
• DOTFM
• 2C-T-21
• 2C-T-21.5
• 2C-T-28
• 3C-P
• Trifluoromescaline