3,4-Ethylenedioxymethcathinone

EDMC
Clinical data
Other names	EDMC; Ethylenedioxymethcathinone; 3,4-Ethylenedioxy-N-methylcathinone; β-Keto-EDMA; BK-EDMA; βk-EDMA
Drug class	Serotonin–norepinephrine–dopamine releasing agent
Identifiers
	IUPAC name 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(methylamino)propan-1-one;
CAS Number	802041-86-7;
PubChem CID	82100609;
ChemSpider	25630609;
UNII	CXT4C5UJ33;
ChEMBL	ChEMBL3604009;
Chemical and physical data
Formula	C12H15NO3
Molar mass	221.256 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C(=O)C1=CC2=C(C=C1)OCCO2)NC;
	InChI InChI=1S/C12H15NO3/c1-8(13-2)12(14)9-3-4-10-11(7-9)16-6-5-15-10/h3-4,7-8,13H,5-6H2,1-2H3; Key:MRFMNGZRIIBJTB-UHFFFAOYSA-N;

3,4-Ethylenedioxymethcathinone, also known as EDMC or 3,4-ethylenedioxy-N-methylcathinone, is a monoamine releasing agent (MRA) of the cathinone family related to methylone (3,4-methylenedioxymethcathinone; MDMC).^[1]^[2]^[3]^[4] It is the β-keto or cathinone analogue of 3,4-ethylenedioxymethamphetamine (EDMA).^[1]^[2]

Quick facts Clinical data, Other names ...

EDMC acts as a serotonin–norepinephrine–dopamine releasing agent (SNDRA).^[3]^[1]^[2] Its EC₅₀Tooltip half-maximal effective concentration values for induction of monoamine release are 347 nM for serotonin, 327 nM for norepinephrine, and 496 nM for dopamine in rat brain synaptosomes.^[1]^[2] These potencies were about 1.4-fold, 2.2-fold, and 3.7-fold lower than those of methylone, respectively.^[1]^[2]

The drug was first described in 2015, whereas EDMA has been described much earlier.^[1]^[2]

See also