3-dehydrosphinganine reductase

3-dehydrosphinganine reductase (EC 1.1.1.102) also known as 3-ketodihydrosphingosine reductase (KDSR) or follicular variant translocation protein 1 (FVT1) is an enzyme that in humans is encoded by the KDSR gene.^{[5][6][7][8][9]}

3-dehydrosphinganine reductase
Identifiers
EC no.	1.1.1.102
CAS no.	37250-36-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

KDSR
Identifiers
Aliases	KDSR, Kdsr, 6330410P18Rik, 9430079B08Rik, Fvt1, DHSR, SDR35C1, 3-ketodihydrosphingosine reductase, 3-dehydrosphinganine reductase, EKVP4
External IDs	OMIM: 136440; MGI: 1918000; HomoloGene: 1539; GeneCards: KDSR; OMA:KDSR - orthologs
EC number	1.1.1.102
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q21.33 Start 63,327,726 bp[1] End 63,367,228 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E2.1 Start 106,648,189 bp[2] End 106,687,457 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell buccal mucosa cell C1 segment nipple skin of leg palpebral conjunctiva epithelium of colon skin of abdomen parotid gland internal globus pallidus Top expressed in decidua gastrula otolith organ utricle cumulus cell retinal pigment epithelium pineal gland iris otic vesicle ciliary body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity 3-dehydrosphinganine reductase activity Cellular component integral component of membrane endoplasmic reticulum membrane endoplasmic reticulum membrane extracellular space Biological process 3-keto-sphinganine metabolic process sphingolipid biosynthetic process lipid metabolism sphingolipid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2531 70750 Ensembl ENSG00000119537 ENSMUSG00000009905 UniProt Q06136 Q6GV12 RefSeq (mRNA) NM_002035 NM_027534 NM_001316750 RefSeq (protein) NP_002026 NP_001303679 NP_081810 Location (UCSC) Chr 18: 63.33 – 63.37 Mb Chr 1: 106.65 – 106.69 Mb PubMed search [3] [4]
Wikidata
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Function

3-dehydrosphinganine reductase catalyzes the chemical reaction:

sphinganine + NADP⁺ ${\displaystyle \rightleftharpoons }$ 3-dehydrosphinganine + NADPH + H⁺

Thus, the two substrates of this enzyme are sphinganine and NADP⁺, whereas its 3 products are 3-dehydrosphinganine, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. This enzyme participates in sphingolipid metabolism.

Tissue distribution

Follicular lymphoma variant translocation 1 is a secreted protein which is weakly expressed in hematopoietic tissue.

Clinical significance

FVT1 shows a high rate of transcription in some T cell malignancies and in phytohemagglutinin-stimulated lymphocytes. The proximity of FVT1 to BCL2 suggests that it may participate in the tumoral process.^[9]