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5-MeO-isoDMT
Serotonergic psychoplastogen From Wikipedia, the free encyclopedia
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5-MeO-isoDMT, or 5-OMe-isoDMT, also known as 5-methoxy-N,N-dimethylisotryptamine, is a putatively non-hallucinogenic serotonin 5-HT2A receptor agonist and psychoplastogen of the isotryptamine group.[1][2][3][4][5][6] It is the isotryptamine analogue of the non-hallucinogenic 6-MeO-DMT and is a positional isomer of the psychedelic 6-MeO-isoDMT.[3][5][6]
The drug does not substitute for serotonergic psychedelics in animal drug discrimination tests and does not produce the head-twitch response, a behavioral of psychedelic effects, at any dose.[1][3][5][7][6] Hence, it appears to be non-hallucinogenic.[3][5][6] On the other hand, 5-MeO-isoDMT has comparable psychoplastogenic potency and effects compared to the psychedelic 5-MeO-DMT.[1][2][4][5] These effects are blocked by the serotonin 5-HT2A receptor antagonist ketanserin.[4][5] Certain analogues and derivatives of 5-MeO-isoDMT, like isoDMT and the α-methylated zalsupindole (DLX-001; AAZ-A-154; (R)-5-MeO-α-methyl-isoDMT), likewise produce no head-twitch response, whereas 6-MeO-isoDMT produces a reduced head-twitch response.[1][4][5][6] Hence, these analogues appear to be less or fully non-hallucinogenic similarly to 5-MeO-isoDMT.[1][4][5][6] In addition, like 5-MeO-isoDMT, they retain potent psychoplastogenic effects.[1][4][5]
5-MeO-isoDMT was first described in the scientific literature by 1984.[6][7] It was subsequently further characterized in 2020.[4][5] Confusingly, the drug has been referred to as "6-MeO-isoDMT" (or rather "6-OMe-isoDMT") in some publications.[3]
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